GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose

Yusaku Iwasaki, Sendo Mio, Katsuya Dezaki, +15

Nature Communications

GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats

Tohru Hira, Taisuke Mochida, Miyashita Kyoko, +1

American Journal of Physiology-Gastrointestinal and Liver Physiology

Ileal ZeinhBiochemistryMedicineFood DigestionPhysiology +13

Calcium‐sensing receptor mediates phenylalanine‐induced cholecystokinin secretion in enteroendocrine STC‐1 cells

Tohru Hira, Shingo Nakajima, Yuzuru Eto, +1

FEBS Journal

Car AntagonistExperimental PharmacologyCellular PhysiologyGastrointestinal Peptide HormoneCell Signaling +14

The Corn Protein, Zein Hydrolysate, Administered into the Ileum Attenuates Hyperglycemia via Its Dual Action on Glucagon-Like Peptide-1 Secretion and Dipeptidyl Peptidase-IV Activity in Rats

Taisuke Mochida, Tohru Hira, Hiroshi Hara

Endocrinology

Rice protein hydrolysates stimulate GLP-1 secretion, reduce GLP-1 degradation, and lower the glycemic response in rats

Yuki Ishikawa, Tohru Hira, Daisuke Inoue, +5

Food & Function

Oral Administration of Corn Zein Hydrolysate Stimulates GLP-1 and GIP Secretion and Improves Glucose Tolerance in Male Normal Rats and Goto-Kakizaki Rats

Noriyuki Higuchi, Tohru Hira, Nao Yamada, +1

Endocrinology

NutritionGoto-kakizaki RatsCorn ZeinGlucose ToleranceInsulin Signaling +16

Soybean β51–63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells

Shingo Nakajima, Tohru Hira, Yuzuru Eto, +2

Regulatory Peptides

Molecular PhysiologySignal TransductionSoybean β51–63 PeptideG Protein-coupled ReceptorMedicine +9

Calcium‐sensing receptor mediates dietary peptide‐induced <scp>CCK</scp> secretion in enteroendocrine <scp>STC</scp>‐1 cells

Shingo Nakajima, Tohru Hira, Hiroshi Hara

Molecular Nutrition & Food Research

Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1)

Rika Nagamine, Shiori Ueno, Masahito Tsubata, +5

Food & Function

NutritionGlycobiologyOral SpInsulin SignalingMetabolic Syndrome +16

Dietary Protein Peptic Hydrolysates Stimulate Cholecystokinin Release via Direct Sensing by Rat Intestinal Mucosal Cells

Takashi Nishi, H Hara, Tohru Hira, +1

Experimental Biology and Medicine

Food ChemistryNutritionBiochemistryWheat GlutenDirect Sensing +12