Michael P. A. Lyle

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

Paul C. McDonald, Stephen Chia, Philippe L. Bédard et al. · American Journal of Clinical Oncology · 2020 · 250 citations · Full text

Medicine, Oncology, Pharmacology +16

Enantioselective Friedel−Crafts Alkylation Reactions Catalyzed by a Chiral Nonracemic <i>C</i>₂-Symmetric 2,2‘-Bipyridyl Copper(II) Complex

Michael P. A. Lyle, N.D. Draper, Peter D. Wilson · Organic Letters · 2005 · 109 citations

Natural Sciences, Chemistry, Catalysis +11

Substituted 6-amino-4H-[1,2]dithiolo[4,3-b]pyrrol-5-ones: Synthesis, structure–activity relationships, and cytotoxic activity on selected human cancer cell lines

Bin Li, Michael P. A. Lyle, Genhui Chen et al. · Bioorganic & Medicinal Chemistry · 2007 · 64 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Synthesis of a New Chiral Nonracemic <i>C</i>₂-Symmetric 2,2‘-Bipyridyl Ligand and Its Application in Copper(I)-Catalyzed Enantioselective Cyclopropanation Reactions

Michael P. A. Lyle, Peter D. Wilson · Organic Letters · 2004 · 60 citations

Natural Sciences, Chemistry, Catalysis +8

Stroma secreted IL6 selects for “stem-like” population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways

Kousik Kesh, Vanessa T. Garrido, Austin R. Dosch et al. · Cell Death and Disease · 2020 · 44 citations · Full text

Medicine, Cell Biology, Oncology +17