Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes

Pratap Karki, Anton Webb, Keisha Smith, +5

Molecular and Cellular Biology

Molecular RegulationGeneticsYin Yang 1Neurochemical BiomarkersSynaptic Signaling +27

Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy

Dineo Khabele, Deok-Soo Son, Angelika K. Parl, +4

Cancer Biology & Therapy

Histone ModificationsEpigenetic ChangeCancer BiologyEpigeneticsTumor Biology +16

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia

Judong Kim, Edward Pajarillo, Asha Rizor, +4

PLoS ONE

ApoptosisImmunologyCell DeathCellular PhysiologyOxidative Stress +19

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro

Deok-Soo Son, Kanji Ushinohama, Xin Gao, +4

Reproductive Toxicology

InfertilityHormonal ContraceptiveFertilityDirect ActionBlocks Ovulation +11

Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1)

Pratap Karki, Clifford Kim, Keisha Smith, +3

Journal of Biological Chemistry

Toxic Equivalency Factors of Polychlorinated Dibenzo-p-dioxins in an Ovulation Model: Validation of the Toxic Equivalency Concept for One Aspect of Endocrine Disruption

Xin Gao, Deok-Soo Son, Paul F. Terranova, +1

Toxicology and Applied Pharmacology

Endocrine DisruptorsInfertilityHormonal ContraceptiveFertilityToxic Equivalency Concept +12

The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity

Edward Pajarillo, Asha Rizor, Deok-Soo Son, +2

Journal of Biological Chemistry

17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity

Edward Pajarillo, James Johnson, Judong Kim, +4

NeuroToxicology

MedicinePhysiologyToxicologyNeuroprotectionEndocrinology +4

Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

James Johnson, Edward Pajarillo, Pratap Karki, +4

NeuroToxicology

Valproic AcidBiochemistryMedicineNeuropharmacologyManganese-induced Reduction +7

Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity

Edward Pajarillo, James Johnson, Asha Rizor, +8

Journal of Biological Chemistry