TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma

Xiaochen Wang, Qifeng He, Haiyuan Shen, +4

Journal of Hepatology

Cancer ImmunosurveillanceMedicineImmunologyCell DeathLiver Cancer +6

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

Huihui Xu, Xiaoyan Wu, Hao Qin, +5

Journal of the American Society of Nephrology

Renal PathologyImmunologyInsulin SignalingRenal FunctionMatrix Biology +18

Brahma-Related Gene 1 Bridges Epigenetic Regulation of Proinflammatory Cytokine Production to Steatohepatitis in Mice

Wenfang Tian, Huihui Xu, Fei Fang, +3

Hepatology

Proinflammatory Stimuli Engage Brahma Related Gene 1 and Brahma in Endothelial Injury

Fei Fang, De‐Wei Chen, Liming Yu, +11

Circulation Research

Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

Xiaochen Wang, Haiyuan Shen, Qifeng He, +3

Journal of Medical Genetics

Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells

Wenfang Tian, Chenzhi Hao, Zhiwen Fan, +7

Journal of Hepatology

ChromatinHepatic Stellate CellsEpigenetic ChangeGene ExpressionEpigenomics +7

ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation

Zechuan Zhang, Xiaoliang Xu, Wenfang Tian, +9

Journal of Hepatology

InflammationGdf15 MaturationMetabolic Associated SteatohepatitisHepatologyNonalcoholic Fatty Liver Disease +7

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

Wenfang Tian, Zhiwen Fan, Jianfei Li, +7

The International Journal of Biochemistry & Cell Biology

Transcriptional RegulationFibrosisSystems BiologyEssential RoleSignaling Pathway +11

MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells

Yuyu Yang, Xian Cheng, Wenfang Tian, +6

Nucleic Acids Research

Inflammatory Lung DiseaseLung InflammationImmunologyEndothelin-induced Pro-inflammatory TranscriptionInnate Immunity +24

MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis

Zhiwen Fan, Chenzhi Hao, Min Li, +9

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

FibrosisDevelopmental BiologyMedicineEpigenetic ModulatorEpigenetic Regulation +2