Thomas D. Madden

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.6K citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +16

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui et al. · Angewandte Chemie International Edition · 2012 · 1.2K citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Norbert Pardi, Steven Tuyishime, Hiromi Muramatsu et al. · Journal of Controlled Release · 2015 · 1K citations

Pharmacy, Molecular Biology, Molecular Pharmaceutics +17

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Norbert Pardi, Michael J. Hogan, Rebecca S. Pelc et al. · Nature · 2017 · 888 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +14