Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells.

Jennings F. Worley, Maggie S. McIntyre, Ben F. Spencer, +3

Journal of Biological Chemistry

Cellular PhysiologyInsulin SignalingInsulin DeliveryCell SignalingCell Physiology +19

Dependence on NADH produced during glycolysis for beta-cell glucose signaling

Iain Dukes, Maggie S. McIntyre, Robert J. Mertz, +4

Journal of Biological Chemistry

Cytosolic Ca2+Metabolic RemodelingCellular PhysiologyInsulin SignalingCytosolic Atp +16

Depletion of intracellular Ca2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells.

Jennings F. Worley, Maggie S. McIntyre, Ben F. Spencer, +1

Journal of Biological Chemistry

Intracellular Ca2+ StoresNeurotransmissionOptogeneticsCellular PhysiologyInsulin Signaling +21

Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes

Yulin Wu, Christopher Aquino, David J. Cowan, +22

Journal of Medicinal Chemistry

Molecular PharmacologyMetabolic SyndromeLipid SynthesisBiochemistryBiliary Tract +11

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea‐pig model

Xiaozhou Yao, D. L. Anderson, Sean Ross, +9

British Journal of Pharmacology

Identification and Structure–Activity Studies of Novel Ultrashort-Acting Benzodiazepine Receptor Agonists

Jeffrey A. Stafford, Gregory J. Pacofsky, Richard F. Cox, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyDrug TargetStructure–activity StudiesBiochemistryMedicine +6

Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

Wieslaw M. Kazmierski, Don L. Anderson, Christopher Aquino, +14

Journal of Medicinal Chemistry

Strong Anti-hiv PotencyImmunologyClinical Compound 122PharmacotherapyAntiviral Drug +15

6-(4-Chlorophenyl)-3-substituted-thieno[3,2-<i>d</i>]pyrimidin-4(3<i>H</i>)-one-Based Melanin-Concentrating Hormone Receptor 1 Antagonist

Francis X. Tavares, Kamal Albarazanji, Michael J. Bishop, +14

Journal of Medicinal Chemistry

ObesityMolecular PharmacologyMetabolic SyndromeMch Receptor 1Energy Homeostasis +13

Propranolol inhibits the human ether-a-go-go-related gene potassium channels

Xiaozhou Yao, Maggie S. McIntyre, Daniel G. Lang, +3

European Journal of Pharmacology

ChannelopathiesMolecular PhysiologySignal TransductionMedicinePhysiology +4

Relating the Structure, Activity, and Physical Properties of Ultrashort-Acting Benzodiazepine Receptor Agonists

Gregory J. Pacofsky, Jeffrey A. Stafford, Richard F. Cox, +12

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +6