HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

Melania Capasso, Mandeep K. Bhamrah, Tom Henley, +14

Nature Immunology

Signal TransductionBcr-dependent GenerationHeme HomeostasisCell SignalingMedicine +8

A generic strategy for CRISPR-Cas9-mediated gene tagging

Daniel H. Lackner, Alexia Carré, Paloma M. Guzzardo, +8

Nature Communications

The miR-155–PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

Dong Lu, Rinako Nakagawa, Sandra Lazzaro, +11

The Journal of Experimental Medicine

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival

Robert B. Henderson, Katarzyna Grys, Anne Vehlow, +6

The Journal of Experimental Medicine

Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids

Mario Mietzsch, Courtnee Eddington, Ariana Jose, +6

Journal of Virology

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial

Emil Lou, Modassir S Choudhry, Timothy K. Starr, +30

The Lancet Oncology

Cancer ImmunosurveillanceMedicineImmunologyColorectal CancerMetastatic Colorectal Cancer +6

MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells

Giuseppina Arbore, Tom Henley, Laura Biggins, +4

Life Science Alliance

EngineeringOptimal ProliferationHumoral ResponseImmunologyCell Cycle +15

Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly

Lydia Viney, Tilmann Bürckstümmer, Courtnee Eddington, +4

Journal of Virology

Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair

Beau R. Webber, Matthew J. Johnson, Joseph G. Skeate, +13

Nature Biomedical Engineering

ChromatinGenome InstabilityT-regulatory CellImmunologyMolecular Biology +5

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

Douglas C. Palmer, Beau R. Webber, Yogin Patel, +35

Internal CheckpointTil SenescenceImmunologyImmune RegulationImmunoediting +18