Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

Kai Li, Lici A. Schurig-Briccio, Xinxin Feng, +25

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistryTuberculosis PreventionChemical BiologyPharmaceutical Chemistry +15

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

Yonghui Zhang, Rong Cao, Fenglin Yin, +21

Journal of the American Chemical Society

Medicinal ChemistryNmr InvestigationBiochemistryMedicineNatural Sciences +12

Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in <i>Staphylococcus aureus</i>: In Vitro, in Vivo, and Crystallographic Results

Yongcheng Song, Chia-I Liu, Fu‐Yang Lin, +9

Journal of Medicinal Chemistry

BacteriologyStaphylococcus AureusMolecular BiologyChemical BiologyBacterial Pathogens +17

Structure of ( <i>E</i> )-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway

Ingo Rekittke, Jochen Wiesner, René C. Röhrich, +9

Journal of the American Chemical Society

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation

M.P. Hudock, Yonghui Zhang, Rey‐Ting Guo, +11

Journal of Medicinal Chemistry

Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

Deu John M. Cruz, Rafaela Milan Bonotto, Rafael Gonçalves Barbosa Gomes, +7

PLoS neglected tropical diseases

Lipophilic analogs of zoledronate and risedronate inhibit <i>Plasmodium</i> geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

Joo Hwan No, Fernando de M. Dossin, Yonghui Zhang, +9

Proceedings of the National Academy of Sciences

Antiparasitic AgentMalariaPlasmodium FalciparumChemical BiologyPharmaceutical Chemistry +16

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

Émilie Durieu, Eric Prina, L Olivier, +12

Antimicrobial Agents and Chemotherapy

Drug TargetParasite ResistanceAntiparasitic AgentImmunologyMolecular Biology +17

Bisphosphonate Inhibition of a<i>Plasmodium</i>Farnesyl Diphosphate Synthase and a General Method for Predicting Cell-Based Activity from Enzyme Data

D. Mukkamala, Joo Hwan No, Lauren M. Cass, +2

Journal of Medicinal Chemistry

Comparative study of different forms of Jellein antimicrobial peptide on Leishmania parasite

Farnaz Zahedifard, Hyeryon Lee, Joo Hwan No, +4

Experimental Parasitology

Bioorganic ChemistryAntiparasitic AgentMedicineParasitic ProtozoaLeishmania Parasite +6