Chloride extrusion enhancers as novel therapeutics for neurological diseases

Martin Gagnon, Marc J. Bergeron, Guillaume Lavertu, +16

Nature Medicine

Neurodegenerative DiseasesNeurologyBiomedical EngineeringTherapeuticsNeuropathology +3

Discovery of 4-Aryl-4<i>H</i>-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-based High-Throughput Screening Assay. 1. Structure−Activity Relationships of the 4-Aryl Group

William Kemnitzer, John Drewe, Songchun Jiang, +18

Journal of Medicinal Chemistry

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 7- and 5-, 6-, 8-positions

William Kemnitzer, Shailaja Kasibhatla, Songchun Jiang, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOxysterolBiochemistryMedicineNatural Sciences +9

Discovery of 4-Aryl-4<i>H</i>-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships of <i>N</i>-Alkyl Substituted Pyrrole Fused at the 7,8-Positions

William Kemnitzer, John Drewe, Songchun Jiang, +11

Journal of Medicinal Chemistry

Chemoprevention StrategyApoptosisCell DeathNew SeriesHeterocycle Chemistry +15

Solution Structure of Human BCL-w

Alexei Yu. Denisov, Murthy S.R. Madiraju, Gang Chen, +5

Journal of Biological Chemistry

Protein FunctionProtein AssemblyBiochemistryProtein FoldingTriple-resonance Nmr Spectroscopy +13

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: Modifications of the 2- and 3-positions

William Kemnitzer, Songchun Jiang, Yan Wang, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOxysterolBiochemistryMedicineNatural Sciences +11

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay

William Kemnitzer, Songchun Jiang, Hong Zhang, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOxysterolBiochemistryMedicineNatural Sciences +9

A novel RGD antagonist that targets both αvβ3 and α5β1 induces apoptosis of angiogenic endothelial cells on type I collagen

Karen Meerovitch, Frédéric Bergeron, Lorraine Leblond, +7

Vascular Pharmacology

InflammationAngiogenesisAngiogenic Endothelial CellsMedicineVascular Pharmacology +11

Two-step synthesis of the bipyrrole precursor of prodigiosins

Kenza Daïri, Sasmita Tripathy, Giorgio Attardo, +1

Tetrahedron Letters

Synthetic ChemistryBipyrrole PrecursorChemistry

Facile Route to 2-Fluoropyridines via 2-Pyridyltrialkylammonium Salts Prepared from Pyridine <i>N</i>-Oxides and Application to ¹⁸F-Labeling

Hui Xiong, Adam T. Hoye, Kuo‐Hsien Fan, +5

Organic Letters

Positron Emission TomographyCombinatorial ChemistryChemical EngineeringEngineeringBiochemistry +12