Identification of a Nuclear Receptor for Bile Acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa, +7

Science

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Joyce J. Repa, Guosheng Liang, Jiafu Ou, +7

Genes & Development

Oxysterol ReceptorsSterol SensorsTranscriptional RegulationDietary CholesterolMetabolic Signaling +14

Role of LXRs in control of lipogenesis

Joshua R. Schultz, Hua Tu, Alvin Luk, +9

Genes & Development

Cell CultureLipid MovementCellular PhysiologyOxidative StressMetabolic Syndrome +17

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

Knut Erik Berge, Hui Tian, Gregory A. Graf, +7

Science

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Paul J. Emmerson, Feng Wang, Yong Du, +21

Nature Medicine

Metabolic SyndromeEnergy MetabolismBiochemistryG Protein-coupled ReceptorMedicine +10

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

Jiafu Ou, Hua Tu, Bei Shan, +5

Proceedings of the National Academy of Sciences

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Joyce Chan, Derek E. Piper, Qiong Cao, +37

Proceedings of the National Academy of Sciences

ImmunologyHyperlipidemiaNonhuman PrimatesImmunotherapyInflammation +16

Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis

Thomas A. Kerr, Shigeru Saeki, Manfred Schneider, +6

Developmental Cell

Signal TransductionBiochemistryBiliary TractMolecular RegulationLiver Physiology +8

CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene

Masahiro Nitta, Sherry Ku, Chaline Brown, +2

Proceedings of the National Academy of Sciences

GeneticsMolecular GeneticsOrphan Nuclear ReceptorCpf Binding SiteCholesterol Homeostasis +20

The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol

Derek E. Piper, Simon Jackson, Qiang Liu, +5

Structure

Crystal StructureProtein FunctionOxysterolBiochemistryNatural Sciences +5