Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

Thomas Wekerle, Josef Kurtz, Hiroshi Ito, +6

Nature Medicine

Cell TherapyTransplantationAutoimmune DiseaseMarrow TransplantationBone Marrow Failure +9

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

Peter Blaha, Sinda Bigenzahn, Zvonimir Koporc, +11

Blood

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death

Thomas Wekerle, Josef Kurtz, Mohamed H. Sayegh, +6

The Journal of Immunology

CD4 T Cell-Mediated Alloresistance to Fully MHC-Mismatched Allogeneic Bone Marrow Engraftment Is Dependent on CD40-CD40 Ligand Interactions, and Lasting T Cell Tolerance Is Induced by Bone Marrow Transplantation with Initial Blockade of this Pathway

Hiroshi Ito, Josef Kurtz, Juanita Shaffer, +1

The Journal of Immunology

Cell TherapyCostimulatory BlockadeT-regulatory CellImmunologyCd4 T Cell Responses +15

Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells

Josef Kurtz, Juanita Shaffer, Ariadne Lie, +3

Blood

Vascularized Composite Allograft Tolerance Across MHC Barriers in a Large Animal Model

David A. Leonard, Josef Kurtz, Christopher Mallard, +10

American Journal of Transplantation

Penis Transplantation

Curtis L. Cetrulo, Kai Li, Harry M. Salinas, +22

Annals of Surgery

Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol

Christoph Domenig, Alberto Sánchez‐Fueyo, Josef Kurtz, +5

The Journal of Immunology

Cell TherapyCreating Mixed ChimerismRadiation EffectNonlymphoablative Irradiation-free ProtocolImmunology +20

Mechanisms Involved in the Establishment of Tolerance Through Costimulatory Blockade and BMT: Lack of Requirement for CD40L‐Mediated Signaling for Tolerance or Deletion of Donor‐reactive CD4+ Cells

Josef Kurtz, Hiroshi Ito, Thomas Wekerle, +2

American Journal of Transplantation

Cell TherapySignal TransductionImmunologyImmune RegulationSelf-tolerance +12

Early regulation of CD8 T cell alloreactivity by CD4⁺CD25^–T cells in recipients of anti‐CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor‐reactive CD8⁺ T cells, precluding a role for sustained regulation

Thomas Fehr, Yasuo Takeuchi, Josef Kurtz, +2

European Journal of Immunology

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationImmunodominance +21