Variant tricarboxylic acid cycle in <i>Mycobacterium tuberculosis</i> : Identification of α-ketoglutarate decarboxylase

Jing Tian, Ruslana Bryk, Manabu Itoh, +2

Proceedings of the National Academy of Sciences

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

Atsuro Nakazato, Kazunari Sakagami, Akito Yasuhara, +5

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical SciencePharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

Formation and morphology of “shish-like” fibril crystals of aliphatic polyesters from the sheared melt

Shinichi Yamazaki, Manabu Itoh, Takuya Oka, +1

European Polymer Journal

Materials SciencePolymer MaterialEngineeringMechanical PropertiesPolymer Science +8

Generation of human adult hepatocyte organoids with metabolic functions

Ryo Igarashi, Mayumi Oda, Ryo Okada, +13

Nature

Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats

Yasushige Akada, Shinichi Ogawa, Ken‐ichi Amano, +4

European Journal of Pharmacology

Molecular PharmacologyPotent Analgesic EffectsHealth SciencesNeurophysiologyPain Medicine +12

Fluid Resuscitation of Hemorrhagic Shock with Hemoglobin Vesicles in Beagle Dogs: Pilot Study

Manabu Yamamoto, Hirohisa Horinouchi, Koichi Kobayashi, +4

Artificial Cells Blood Substitutes and Biotechnology

Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as a Factor Xa Inhibitor. II. Substituent Effect on Biological Activities.

Hidemitsu Nishida, Yutaka Miyazaki, Takafumi Mukaihira, +11

Chemical and Pharmaceutical Bulletin

PharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryThrombosis +18

The first total synthesis of calbistrin A, a microbial product possessing multiple bioactivities

Kuniaki Tatsuta, Manabu Itoh, Ryusuke Hirama, +2

Tetrahedron Letters

BiosynthesisCalbistrin AEngineeringBiotransformationFirst Total Synthesis +7

Isolation of 1,5-dideoxy-1,5-imino-D-mannitol from culture broth of Streptomyces species.

Yohji Ezure, Nobutoshi Ojima, Kiyotaka Konno, +5

The Journal of Antibiotics

Smectic A Formation by Twin Dimers Assuming U-shaped Conformation

Y. Naito, Ryohei Ishige, Manabu Itoh, +2

Chemistry Letters

Crystal StructureTwin MoleculesEngineeringPhysicsSa Phase +10