Central Hypotensive Effects of the α _2a -Adrenergic Receptor Subtype

Leigh B. MacMillan, Lutz Hein, Marta S. Smith, +2

Science

Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

Dale S. Edgerton, Guillaume Kraft, Marta S. Smith, +6

JCI Insight

Glucose ProductionFatty Liver DiseaseIndirect Liver EffectsInsulin SignalingMetabolic Syndrome +18

Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs

Christopher J. Ramnanan, Viswanathan Saraswathi, Marta S. Smith, +9

Journal of Clinical Investigation

Glucose ProductionInsulin SignalingMetabolic SyndromeHypothalamic PeptideBrain Hyperinsulinemia +16

Identification of the mRNA for the novel alpha 1D-adrenoceptor and two other alpha 1-adrenoceptors in vascular smooth muscle.

Michael T. Piascik, Marta S. Smith, Edward E. Soltis, +1

Molecular Pharmacology

Novel PEGylated Basal Insulin LY2605541 Has a Preferential Hepatic Effect on Glucose Metabolism

Mary Courtney Moore, Marta S. Smith, Vikram Sinha, +4

Diabetes

Insulin SignalingMetabolic SyndromeIntraportal GlucagonGlucose MetabolismInsulin Delivery +19

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Justin M. Gregory, T. Jordan Smith, James C. Slaughter, +11

Diabetes

Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake

Katie C. Coate, Melanie Scott, Ben Farmer, +6

American Journal of Physiology-Endocrinology and Metabolism

Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog

Christopher J. Ramnanan, Guillaume Kraft, Marta S. Smith, +8

Diabetes

Brain Insulin ActionConscious DogInsulin SignalingGastrointestinal Peptide HormoneMetabolic Syndrome +19

Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs

Noelia Rivera, Christopher J. Ramnanan, Zhibo An, +8

Journal of Clinical Investigation

PathologyInsulin SignalingMetabolic SyndromeType 1Glycogen Metabolism +14

Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis

Jason J. Winnick, Guillaume Kraft, Justin M. Gregory, +11

Journal of Clinical Investigation

Fatty Liver DiseaseInsulin SignalingMetabolic SyndromeType 1Glycogen Content +20