CC2D2A Is Mutated in Joubert Syndrome and Interacts with the Ciliopathy-Associated Basal Body Protein CEP290

Nicholas T. Gorden, Heleen H. Arts, Melissa A. Parisi, +32

The American Journal of Human Genetics

Molecular NeuroscienceJoubert SyndromeMedicineGeneticsGenetic Disorder +5

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

Kelly N. Owens, Felipe Santos, Brock Roberts, +6

PLoS Genetics

Aminoglycoside SusceptibilityExperimental BiologyCellular PhysiologyToxicological MechanismDrug Resistance +18

Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways

Kelly N. Owens, Allison B. Coffin, Lisa S. Hong, +3

Hearing Research

Developmental BiologyCell SignalingAminoglycosides RevealsPhysiologyApoptosis +9

Ultrastructural analysis of aminoglycoside‐induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response

Kelly N. Owens, Dale E. Cunningham, Glen MacDonald, +3

The Journal of Comparative Neurology

Genomic Views of Human History

Kelly N. Owens, Mary‐Claire King

Science

Historical PuzzlesNew ToolsGenomic ViewsHuman VariationMedicine +12

Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line

Allison B. Coffin, Katherine E. Reinhart, Kelly N. Owens, +2

Hearing Research

Animal PhysiologyCell PhysiologyExperimental BiologyExtracellular Divalent CationsPhysiology +7

Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line

Parhum Namdaran, Katherine E. Reinhart, Kelly N. Owens, +2

Journal of Neuroscience

Zebrafish Lateral LineHair Cell RegenerationCell CultureCell ProliferationCytoskeleton +17

Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin

Anna Vlasits, Julian A. Simon, David W. Raible, +2

Hearing Research

Pharmaceutical ScienceBiochemistryMedicineProtect Hair CellsDrug Development +4

Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss

Sarwat Chowdhury, Kelly N. Owens, R. Jason Herr, +7

Journal of Medicinal Chemistry

The zebrafish<i>merovingian</i>mutant reveals a role for pH regulation in hair cell toxicity and function

Tamara M. Stawicki, Kelly N. Owens, Tor Linbo, +3

Disease Models & Mechanisms

Experimental BiologyMolecular RegulationCytoskeletonRedox BiologyCellular Physiology +17