Substrate properties of C1 inhibitor Ma (alanine 434—-glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status

Karen Skriver, William R. Wikoff, P A Patston, +4

Journal of Biological Chemistry

Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease

Douglas G. Walker, Osamu Yasuhara, P A Patston, +2

Brain Research

Complement SystemAlzheimer's DiseaseMedicineComplement C1 InhibitorPharmacology +10

Effects of diet and of alloxan-diabetes on the activity of branched-chain 2-oxo acid dehydrogenase complex and of activator protein in rat tissues

P A Patston, J. Espinal, P J Randle

Biochemical Journal

Lipid PeroxidationOxidative StressTotal ActivitiesMetabolic SyndromeSkeletal Muscle +15

Reactivity of alpha 1-antitrypsin mutants against proteolytic enzymes of the kallikrein-kinin, complement, and fibrinolytic systems.

P A Patston, Nady Roodi, Jürg A. Schifferli, +3

Journal of Biological Chemistry

Fibrinolytic SystemsImmunologyMolecular BiologyAlpha 1-Antitrypsin Arg358Inflammation +22

Formation and properties of C1‐inhibitor polymers

P A Patston, J Hauert, Monique Michaud, +1

FEBS Letters

A common neoepitope is created when the reactive center of C1-inhibitor is cleaved by plasma kallikrein, activated factor XII fragment, C1 esterase, or neutrophil elastase.

Ariane de Agostini, P A Patston, V Marottoli, +3

Journal of Clinical Investigation

C1 EsteraseImmunologyPathologyPharmacotherapyProteomic Technology +15

Rat tissue concentrations of branched-chain 2-oxo acid dehydrogenase complex. Re-evaluation by immunoassay and bioassay

P A Patston, J. Espinal, Jacqueline Shaw, +1

Biochemical Journal

Redox BiologyOxidative StressMitochondrial BiogenesisBioanalysisRabbit Polyclonal Antibody +16

The reaction between plasmin and C1-inhibitor results in plasmin inhibition by the serpin mechanism

Ed Brown, Sriram Ravindran, P A Patston

Blood Coagulation & Fibrinolysis

PharmacotherapyC1-inhibitor ResultsProtein RefoldingEnzymatic ModificationProtein Purification +17

Purification and properties of a protein activator of phosphorylated branched-chain 2-oxo acid dehydrogenase complex

J. Espinal, P A Patston, Hasmukh R. Fatania, +2

Biochemical Journal

Protein ActivatorAldehyde DehydrogenaseCellular EnzymologyBiochemistryMitochondrial Function +13

A Database of Recombinant Wild-type and Mutant Serpins

P A Patston, Peter G.W. Gettins

Thrombosis and Haemostasis

BiologyMutant SerpinsReverse GeneticsGeneticsDirected Evolution +4