Christian Haupt

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

Gernot Habicht, Christian Haupt, Ralf P. Friedrich et al. · Proceedings of the National Academy of Sciences · 2007 · 213 citations · Full text

Protein Assembly, Peptide Engineering, Molecular Biology +17

Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

Lynn Radamaker, Julian Baur, Stefanie Huhn et al. · Nature Communications · 2021 · 118 citations · Full text

Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM

Lynn Radamaker, Sara Karimi-Farsijani, Giada Andreotti et al. · Nature Communications · 2021 · 95 citations · Full text

Protein Function, Protein Assembly, Protein Folding +13

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe et al. · Nature Communications · 2021 · 85 citations · Full text

Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis

Shobini Jayaraman, Donald Gantz, Christian Haupt et al. · Proceedings of the National Academy of Sciences · 2017 · 71 citations · Full text