Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

Gernot Habicht, Christian Haupt, Ralf P. Friedrich, +11

Proceedings of the National Academy of Sciences

Protein AssemblyPeptide EngineeringMolecular BiologyAβ ProtofibrilsAnalytical Ultracentrifugation +15

Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

Lynn Radamaker, Julian Baur, Stefanie Huhn, +6

Nature Communications

Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM

Lynn Radamaker, Sara Karimi-Farsijani, Giada Andreotti, +15

Nature Communications

Protein FunctionProtein AssemblyProtein FoldingPost-translational ModificationsSystemic Al Amyloidosis +11

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

Akanksha Bansal, Matthias Schmidt, Matthies Rennegarbe, +6

Nature Communications

Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis

Shobini Jayaraman, Donald Gantz, Christian Haupt, +1

Proceedings of the National Academy of Sciences

Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo

Karthikeyan Annamalai, Falk Liberta, M.-T. Vielberg, +12

Angewandte Chemie International Edition

Gate-Recessed AlGaN/GaN Based Enhancement-Mode High Electron Mobility Transistors for High Frequency Operation

Stephan Maroldt, Christian Haupt, W. Pletschen, +5

Japanese Journal of Applied Physics

Structural Basis of β‐Amyloid‐Dependent Synaptic Dysfunctions

Christian Haupt, Jörg Leppert, Raik Rönicke, +7

Angewandte Chemie International Edition

Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits

Marius Kollmer, Katrin Meinhardt, Christian Haupt, +15

Proceedings of the National Academy of Sciences

Cellular mechanism of fibril formation from serum amyloid A1 protein

Stéphanie Claus, Katrin Meinhardt, Tobias Aumüller, +7

EMBO Reports

Alzheimer's DiseaseBiochemistryProtein FoldingNatural SciencesCellular Mechanism +5