Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

Mhairi Copland, Ashley Hamilton, Lucy J. Elrick, +6

Blood

Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

Cristian Bellodi, Maria Rosa Lidonnici, Ashley Hamilton, +18

Journal of Clinical Investigation

Mixed-phenotype Acute LeukemiaApoptosisImmunologyCell DeathStem Cell Biology +19

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

Ashley Hamilton, G. Vignir Helgason, Mirle Schemionek, +9

Blood

Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

Mary T. Scott, Koorosh Korfi, Peter Saffrey, +14

Cancer Discovery

BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors

Mhairi Copland, Francesca Pellicano, Linda Richmond, +5

Blood

Versatile humanized niche model enables study of normal and malignant human hematopoiesis

Ander Abarrategi, Katie Foster, Ashley Hamilton, +5

Journal of Clinical Investigation

Tissue EngineeringCell TherapyEngineeringBlood CellPathology +21

Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia

Alexander Waclawiczek, Ashley Hamilton, Kevin Rouault‐Pierre, +8

Journal of Clinical Investigation

Mixed-phenotype Acute LeukemiaImmunologyStanniocalcin 1Stem Cell BiologyMesenchymal Niche +15

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

Mirle Schemionek, Christian Elling, Ulrich Steidl, +14

Blood

BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry

Ashley Hamilton, Lucy J. Elrick, Svetlana Myssina, +4

Leukemia

Hematological MalignancyFlow CytometryMedicinePharmacologyHematology +10

Responsible Property Investing in Canada: Factoring Both Environmental and Social Impacts in the Canadian Real Estate Market

Tessa Hebb, Ashley Hamilton, Heather Hachigian

Journal of Business Ethics

HousingPublic PolicyEconomicsSocial ImpactsProperty Evaluation +11