Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

Kevin C. O’Connor, Katherine A. McLaughlin, Philip L. De Jager, +23

Nature Medicine

Autoimmune DiseaseAllergyAutoantibody ProductionSelf-antigen TetramersMedicine +10

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Raju Kapoor, Pei‐Ran Ho, Nolan Campbell, +182

The Lancet Neurology

Disease ProgressionNeurological DisorderImmunologyClinical TrialsNeurology +6

Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study

Krzysztof Selmaj, David K.B. Li, Hans-Peter Hartung, +12

The Lancet Neurology

Relapsing-remitting Multiple SclerosisDisease ProgressionNeurological DisorderMedicineClinical Trials +5

Peripheral blood γ‐δ T cells lyse fresh human brain—Derived oligodendrocytes

Mark S. Freedman, Theodora C.G. Ruijs, Liisa K. Selin, +1

Annals of Neurology

NKG2D-Mediated Cytotoxicity toward Oligodendrocytes Suggests a Mechanism for Tissue Injury in Multiple Sclerosis

Philippe Saikali, Jack P. Antel, Jia Newcombe, +7

Journal of Neuroscience

Cytokine induction of heat shock protein expression in human oligodendrocytes: An interleukin-1-mediated mechanism

Sameer D. D'Souza, Jack P. Antel, Mark S. Freedman

Journal of Neuroimmunology

InflammationCytokineSignal TransductionHyperthermiaHuman Oligodendrocytes +10

Differential expression of heat shock proteins by human glial cells

Mark S. Freedman, Natalie Buu, Theodora C.J. Ruijs, +2

Journal of Neuroimmunology

Protein FunctionSignal TransductionHyperthermiaHeat Shock ProteinsMolecular Biology +7

Mechanism of γδ T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis

Rana Zeine, Robert A. Pon, Uma Ladiwala, +3

Journal of Neuroimmunology

MedicineImmunologyCell DeathBrain-immune InteractionNeurology +4

Prostaglandin D Synthase Concentration in Cerebrospinal Fluid and Serum of Patients with Neurological Disorders

Dimitrios N Melegos, Mark S. Freedman, Eleftherios P. Diamandis

Prostaglandins

Neurodegenerative DiseasesCreutzfeldt-jakob DiseaseNeurophysiologyMedicineCerebrospinal Fluid +9

Human oligodendrocytes are susceptible to cytolysis by major histocompatibility complex class I-restricted lymphocytes

Theodora C.G. Ruijs, Mark S. Freedman, Yannick Grenier, +2

Journal of Neuroimmunology

Human CellAutoimmune DiseaseHuman OligodendrocytesGranulocyteImmunology +8