Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

Madlen Matz‐Soja, Christiane Rennert, Kristin Schönefeld, +11

eLife

Fatty Liver DiseaseLipogenic Transcription FactorsOxidative StressMetabolic SyndromePotent Regulator +17

Prolonged Lipid Accumulation in Cultured Primary Human Hepatocytes Rather Leads to ER Stress than Oxidative Stress

Christiane Rennert, Theresa Heil, Gerda Schicht, +5

International Journal of Molecular Sciences

Lipid PeroxidationEr StressFatty Liver DiseaseRedox BiologyOxidative Stress +18

Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis

Eugenia Marbach-Breitrück, Madlen Matz‐Soja, Ute Abraham, +16

Journal of Hepatology

InflammationAllergyAutoimmune DiseaseTick-tock Hedgehog-mutual CrosstalkMedicine +7

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

Erik Kolbe, Susanne Aleithe, Christiane Rennert, +18

Cell Reports

Effect of glucose and insulin supplementation on the isolation of primary human hepatocytes

Georg Damm, Gerda Schicht, Andrea Zimmermann, +6

PubMed

RNAi in murine hepatocytes: the agony of choice—a study of the influence of lipid-based transfection reagents on hepatocyte metabolism

J Böttger, Katrin Arnold, Carlo Thiel, +7

Archives of Toxicology

HepatologyBiochemistryChoice—a StudyLiver PhysiologyNatural Sciences +11

The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism – A Systems Biology Analysis Using Self-Organizing Maps

Christiane Rennert, Sebastian Vlaic, Eugenia Marbach-Breitrück, +5

Frontiers in Physiology

Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility

Christiane Rennert, Franziska Eplinius, Ute Hofmann, +7

Archives of Toxicology

InfertilityConditional LossDevelopmental BiologyFertilityFemale Infertility +10

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver

Luise Spormann, Christiane Rennert, Erik Kolbe, +6

Cells

MitophagyMetabolic RemodelingTransgenic Mouse ModelSignaling PathwayNutrient Signalling +21