In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate.

K Ashizawa, Mark C. Willingham, Chen Liang, +1

Journal of Biological Chemistry

GlycobiologySubtype M2Monomer-specific Monoclonal AntibodyMetabolic RemodelingCellular Physiology +18

Hypermutable myotonic dystrophy CTG repeats in transgenic mice

Darren G. Monckton, Mary I. Coolbaugh, K Ashizawa, +2

Nature Genetics

Mendelian DisorderGenetic DisorderGeneticsDegenerative DiseaseTransgenic Mice

Variable transcriptional activity and ligand binding of mutant beta 1 3,5,3'-triiodothyronine receptors from four families with generalized resistance to thyroid hormone.

Christoph A. Meier, Bruce Dickstein, K Ashizawa, +7

Molecular Endocrinology

Molecular BiologyReceptor Expression VectorLigand BindingGeneralized ResistanceTranscriptional Regulation +14

Untreated Graves' disease patients without clinical ophthalmopathy demonstrate a high frequency of extraocular muscle (EOM) enlargement by magnetic resonance.

MARIA C. VILLADOLID, Naokata Yokoyama, Motomori Izumi, +6

The Journal of Clinical Endocrinology & Metabolism

Extraocular MuscleOphthalmologyOculoplasticsThyroid DiseaseMagnetic Resonance +11

Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta. T3 response element-dependent dominant negative potency.

Christoph A. Meier, Clifford Parkison, A Chen, +5

Journal of Clinical Investigation

H-tr BetaGeneticsMolecular BiologyDominant Negative PotencyGeneralized Resistance +15

Phosphorylation stimulates the transcriptional activity of the human beta 1 thyroid hormone nuclear receptor.

Kwang‐Huei Lin, K Ashizawa, Sheue-yann Cheng

Proceedings of the National Academy of Sciences

Molecular BiologyEscherichia ColiTranscriptional RegulationReceptor Tyrosine KinaseNeuroendocrine Mechanism +20

Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.

Manoj K. Bhat, K Ashizawa, Sheue-yann Cheng

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyBeta HeterodimerTranscriptional RegulationSignaling Pathway +18

Regulation of thyroid hormone receptor-mediated transcription by a cytosol protein.

K Ashizawa, Sheue-yann Cheng

Proceedings of the National Academy of Sciences

Thyroid Hormone ReceptorsMolecular RegulationTranscriptional RegulationCellular Regulatory MechanismThyroid Hormone Receptor +18

Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression

Shunichi Yamashita, Hironori Kimura, K Ashizawa, +4

Journal of Endocrinology

InflammationCytokineAutoimmune DiseaseThyroid Hormone SynthesisTg Mrna +9

INTERFERON-_yINHIBITS THYROTROPIN-INDUCED THYROIDAL PEROXIDASE GENE EXPRESSION IN CULTURED HUMAN THYROCYTES

K Ashizawa, Shunichi Yamashita, Yuji Nagayama, +4

The Journal of Clinical Endocrinology & Metabolism