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Publications
8
Citations
1.1K
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Active since
2000
Affiliations
University Hospital of Zurich(Current)
University of Manchester
University of Sheffield
Royal Hallamshire Hospital
Siân H. Leech is an author at University Hospital of Zurich specializing in life sciences, molecular biology, and molecular oncology.
Publications per year
2000–2008
A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.
Robert A. Olie, Ana Paula Simões‐Wüst, Bettina Baumann et al. · PubMed · 2000 · 492 citations
Life Sciences, Molecular Biology, Oncology +17
A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.
Uwe Zangemeister‐Wittke, Siân H. Leech, Robert A. Olie et al. · PubMed · 2000 · 155 citations
Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins
Oliver Gautschi, Stefan Tschopp, Robert A. Olie et al. · JNCI Journal of the National Cancer Institute · 2001 · 149 citations
Life Sciences, Molecular Biology, Oncology +13
Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak
Gareth Griffiths, Bernard M. Corfe, Peter Savory et al. · Oncogene · 2001 · 83 citations
Life Sciences, Cell Biology, Molecular Biology +15
Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding
Haridasan Chirakkal, Siân H. Leech, Karen E. Brookes et al. · Oncogene · 2006 · 70 citations
Life Sciences, Molecular Biology, Nutritional Sciences +11
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