Siân H. Leech

A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.

Robert A. Olie, Ana Paula Simões‐Wüst, Bettina Baumann et al. · PubMed · 2000 · 492 citations

Apoptosis Protein, Apoptosis, Cell Death +17

A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.

Uwe Zangemeister‐Wittke, Siân H. Leech, Robert A. Olie et al. · PubMed · 2000 · 155 citations

Apoptosis, Immunology, Cell Death +17

Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins

Oliver Gautschi, Stefan Tschopp, Robert A. Olie et al. · JNCI Journal of the National Cancer Institute · 2001 · 149 citations

Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak

Gareth Griffiths, Bernard M. Corfe, Peter Savory et al. · Oncogene · 2001 · 83 citations

Cellular Damage Signals, Protein Function, Signal Transduction +12

Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding

Haridasan Chirakkal, Siân H. Leech, Karen E. Brookes et al. · Oncogene · 2006 · 69 citations

Signal Transduction, Signaling Pathway, Mucosal Immunology +8