The whole-genome landscape of medulloblastoma subtypes

Paul A. Northcott, Ivo Buchhalter, A. Sorana Morrissy, +84

Nature

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Paul A. Northcott, David Shih, John Peacock, +131

Nature

GeneticsGenomicsCancer BiologyTumor BiologyNeuro-oncology +21

Childhood cerebellar tumours mirror conserved fetal transcriptional programs

Maria Vladoiu, Ibrahim El-Hamamy, Laura Donovan, +36

Nature

Cell LineageDevelopmental BiologyMedicineCell BiologyEpigenetics +1

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

Paul A. Northcott, Yukiko Nakahara, Xiaochong Wu, +24

Nature Genetics

Histone ModificationsChromatinHistone Lysine MethylationChromatin RemodelingGenetic Disorder +9

Clonal selection drives genetic divergence of metastatic medulloblastoma

Xiaochong Wu, Paul A. Northcott, Adrian M. Dubuc, +29

Nature

Somatic VariantTumor HeterogeneityMedicineGeneticsPathology +3

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

Gabriel Leprivier, Marc Remke, Barak Rotblat, +36

Cell

Signal TransductionSignaling PathwayMolecular RegulationNutrient DeprivationCellular Biochemistry +7

Divergent clonal selection dominates medulloblastoma at recurrence

A. Sorana Morrissy, Livia Garzia, David Shih, +134

Nature

Neuro-oncologySomatic VariantTumor HeterogeneityMedicineGenetics +3

Cytogenetic Prognostication Within Medulloblastoma Subgroups

David Shih, Paul A. Northcott, Marc Remke, +89

Journal of Clinical Oncology

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma

Laura Donovan, Alberto Delaidelli, Sujith K. Joseph, +53

Nature Medicine

Neuro-oncologyCar T CellsCerebrospinal FluidLocoregional DeliverySurgery +3

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Stephen C. Mack, Kristian W. Pajtler, Lukas Chávez, +72

Nature

OncologyNovel TherapyOncogenic AgentMedicinePathology +5