Pegvaliase for the treatment of phenylketonuria: Results of a long-term phase 3 clinical trial program (PRISM)

Janet A. Thomas, Harvey L. Levy, Stephen Amato, +13

Molecular Genetics and Metabolism

Loss of Raltegravir Susceptibility by Human Immunodeficiency Virus Type 1 Is Conferred via Multiple Nonoverlapping Genetic Pathways

Signe Fransen, Soumi Gupta, Robert M. Danovich, +5

Journal of Virology

Viral ReplicationGeneticsImmunologyHuman RetrovirusResistance Mutation (Virology) +14

Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy

Hiroyu Hatano, Harry Lampiris, Signe Fransen, +8

JAIDS Journal of Acquired Immune Deficiency Syndromes

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials

Soumi Gupta, Kelly Lau, Cary O. Harding, +12

EBioMedicine

Combinations of Mutations in the Connection Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Assessing the Impact on Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitor Resistance

Soumi Gupta, Signe Fransen, Ellen E. Paxinos, +3

Antimicrobial Agents and Chemotherapy

Viral ReplicationGeneticsImmunologyConnection DomainMolecular Biology +16

The K101P and K103R/V179D Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nonnucleoside Reverse Transcriptase Inhibitors

Neil Parkin, Soumi Gupta, Colombe Chappey, +1

Antimicrobial Agents and Chemotherapy

GeneticsImmunologyGenetic EpidemiologyMolecular BiologyK103r/v179d Mutations +19

Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates

Fan Yang, Kathryn Patton, Theresa Kasprzyk, +5

Gene Therapy

Substitutions at Amino Acid Positions 143, 148, and 155 of HIV-1 Integrase Define Distinct Genetic Barriers to Raltegravir Resistance <i>In Vivo</i>

Signe Fransen, Soumi Gupta, Arne Frantzell, +2

Journal of Virology

Characterization of Human Immunodeficiency Virus Gag-Specific Gamma Interferon-Expressing Cells following Protective Mucosal Immunization with Alphavirus Replicon Particles

Soumi Gupta, Janani Ramesh, Qian Bin, +9

Journal of Virology

Comparison of Human Immunodeficiency Virus Type 1 Tropism Profiles in Clinical Samples by the Trofile and MT-2 Assays

Eoin Coakley, Jacqueline D. Reeves, Wei Huang, +8

Antimicrobial Agents and Chemotherapy