Immune function in mice lacking the perforin gene.

Craig M. Walsh, Mehrdad Matloubian, C C Liu, +7

Proceedings of the National Academy of Sciences

InflammationKnockout MouseInnate Immune SystemImmunologyImmune Regulation +13

Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor.

J D Young, C C Liu, Georgina S. Butler, +2

Proceedings of the National Academy of Sciences

Laboratory ImmunologyMast Cell DisorderImmunologyImmune RegulationCell Death +18

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

Clay W. Scott, Russell C. Spreen, Joseph L. Herman, +4

Journal of Biological Chemistry

Molecular BiologyCytoskeletonTau ProteinCellular PhysiologyAlzheimer's Disease +16

Characterization of a membrane pore-forming protein from Entamoeba histolytica.

J D Young, Tsen Men Young, Lily Lu, +2

The Journal of Experimental Medicine

Proteinlipid InteractionProtein SecretionBiochemistryArtificial Planar BilayersMembrane Transport +13

Cytolytic lymphocytes induce both apoptosis and necrosis in target cells

Arturo Zychlinsky, Lan Zheng, C C Liu, +1

The Journal of Immunology

Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

Dandan Sun, Shuwei Jiang, Lan Zheng, +2

The Journal of Experimental Medicine

Dna FragmentationApoptosisMolecular BiologyCell DeathPathology +17

Expression of perforin and serine esterases by human gamma/delta T cells.

Hirotaka Koizumi, C C Liu, Lan Zheng, +4

The Journal of Experimental Medicine

T-regulatory CellImmunologyImmune RegulationCell DeathNk Cells +18

Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules.

J D Young, Eckhard R. Podack, Zanvil A. Cohn

The Journal of Experimental Medicine

Circular LesionsProtein SecretionProteinlipid InteractionImmunologyAntigen Processing +21

In vivo expression of perforin by CD8+ lymphocytes in autoimmune disease. Studies on spontaneous and adoptively transferred diabetes in nonobese diabetic mice.

Lucy H. Young, Laurence B. Peterson, Linda S. Wicker, +2

The Journal of Immunology

ImmunologyNk CellsPathologyCell DeathImmunotherapy +18

Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells.

C C Liu, B Perussia, Zanvil A. Cohn, +1

The Journal of Experimental Medicine

Innate Immune SystemImmunologyNk CellsPathologyImmunologic Mechanism +20