Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase

Allen Krantz, Robin W. Spencer, Tim F. Tam, +4

Journal of Medicinal Chemistry

1,2,4-Thiadiazole: A novel Cathepsin B inhibitor

Régis Leung-Toung, Jolanta Wodzinska, Wanren Li, +5

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMedicinePharmacotherapyPharmacology +3

Ynenol lactones: synthesis and investigation of reactions relevant to their inactivation of serine proteases

Robin W. Spencer, Tim F. Tam, Everton M. Thomas, +2

Journal of the American Chemical Society

Molecular SciencesBiosynthesisBioorganic ChemistryBiochemistryEngineering +13

Synthesis of 3-Substituted Bicyclic Imidazo[1,2-<i>d</i>][1,2,4]thiadiazoles and Tricyclic Benzo[4,5]imidazo[1,2-<i>d</i>][1,2,4]thiadiazoles

Régis Leung-Toung, Tim F. Tam, Yanqing Zhao, +4

The Journal of Organic Chemistry

HeterocyclicSelective MethylationBiochemistryNatural SciencesCyanogen Bromide +6

Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides

Tim F. Tam, Julie Carriere, Isaiah MacDonald, +6

Journal of Medicinal Chemistry

Peptide EngineeringImmunologyAltmetric Attention ScoreMolecular BiologyPeptide Science +23

Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation

Allen Krantz, Robin W. Spencer, Tim F. Tam, +2

Journal of Medicinal Chemistry

Pharmaceutical ScienceSerine ProteasesAlternate Substrate InhibitorsChemical BiologyEnzymatic Modification +17

Novel suicide inhibitors of serine proteinases. Inactivation of human leukocyte elastase by ynenol lactones

Tim F. Tam, Robin W. Spencer, Everton M. Thomas, +2

Journal of the American Chemical Society

Molecular PharmacologyBiochemistryMedicineImmunologyAltmetric Attention Score +10

Chiral models of the furenone moiety of germacranolide sesquiterpenes

Tim F. Tam, Bert Fraser‐Reid

The Journal of Organic Chemistry

DatabasesAltmetric Attention ScoreBibliometricsOrganic ChemistryBert Fraser-reidcite +14

Inhibition of serine proteases by benzoxazinones: effects of electron withdrawal and 5-substitution

Robin W. Spencer, Leslie J. Copp, Bonnie J. Bonaventura, +4

Biochemical and Biophysical Research Communications

Electron WithdrawalBiochemistryMedicineSerine ProteasesPharmacology +2

3-Substituted Imidazo[1,2-<i>d</i>][1,2,4]-thiadiazoles:  A Novel Class of Factor XIIIa Inhibitors

Régis Leung-Toung, Tim F. Tam, Jolanta Wodzinska, +5

Journal of Medicinal Chemistry