Everton M. Thomas

Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase

Allen Krantz, Robin W. Spencer, Tim F. Tam et al. · Journal of Medicinal Chemistry · 1990 · 269 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Ynenol lactones: synthesis and investigation of reactions relevant to their inactivation of serine proteases

Robin W. Spencer, Tim F. Tam, Everton M. Thomas et al. · Journal of the American Chemical Society · 1986 · 59 citations

Life Sciences, Biochemistry, Chemistry +6

Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides

Tim F. Tam, Julie Carriere, Isaiah MacDonald et al. · Journal of Medicinal Chemistry · 1992 · 32 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation

Allen Krantz, Robin W. Spencer, Tim F. Tam et al. · Journal of Medicinal Chemistry · 1987 · 30 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15

Novel suicide inhibitors of serine proteinases. Inactivation of human leukocyte elastase by ynenol lactones

Tim F. Tam, Robin W. Spencer, Everton M. Thomas et al. · Journal of the American Chemical Society · 1984 · 29 citations

Life Sciences, Biochemistry, Pharmacology +8