Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

C.A. Stein, Jens Bo Hansen, Johnathan C. Lai, +12

Nucleic Acids Research

EngineeringMolecular BiologyGene DeliveryBiomedical EngineeringCellular Physiology +18

A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC

Johnathan C. Lai, Wenzhi Tan, Luba Benimetskaya, +3

Proceedings of the National Academy of Sciences

MitophagyApoptosisMolecular BiologyCell DeathCancer Biology +20

Inhibition of Potentially Anti-Apoptotic Proteins by Antisense Protein Kinase C-α (Isis 3521) and Antisense bcl-2 (G3139) Phosphorothioate Oligodeoxynucleotides: Relationship to the Decreased Viability of T24 Bladder and PC3 Prostate Cancer Cells

Luba Benimetskaya, Paul S. Miller, Simon Benimetsky, +7

Molecular Pharmacology

Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease

Luba Benimetskaya, Sijian Wu, Anatoliy M. Voskresenskiy, +7

Blood

Antisense RNA Down-Regulation of bcl-2 Expression in DU145 Prostate Cancer Cells Does Not Diminish the Cytostatic Effects of G3139 (Oblimersen)

Anthony J. Raffo, Johnathan C. Lai, C.A. Stein, +4

Clinical Cancer Research

G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.

Jonathan C. Lai, Luba Benimetskaya, Regina M. Santella, +3

PubMed

ApoptosisMolecular BiologyCell DeathCancer BiologyTumor Biology +17

G3139 and Other CpG-Containing Immunostimulatory Phosphorothioate Oligodeoxynucleotides Are Potent Suppressors of the Growth of Human Tumor Xenografts in Nude Mice

Volker Gekeler, Petra Gimmnich, Hans-Peter Hofmann, +13

Oligonucleotides

ImmunologyImmunoeditingCell DeathImmunotherapyCancer Biology +14

Antisense RNA down-regulation of bcl-xL Expression in prostate cancer cells leads to diminished rates of cellular proliferation and resistance to cytotoxic chemotherapeutic agents.

Maria Vilenchik, Anthony J. Raffo, Luba Benimetskaya, +2

PubMed

Bcl-xl CdnaCell RegulationMedicineCancer Cell BiologyAntisense Rna Down-regulation +10

Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells

Johnathan C. Lai, Luba Benimetskaya, Anastasia Khvorova, +4

Molecular Cancer Therapeutics

Relative Bcl-2 Independence of Drug-Induced Cytotoxicity and Resistance in 518A2 Melanoma Cells

Luba Benimetskaya, Johnathan C. Lai, Anastasia Khvorova, +5

Clinical Cancer Research