In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.

Godefridus J. Peters, Gilberto Schwartsmann, Jorge Nadal, +4

PubMed

Mitochondrial PyrimidinePharmacotherapyExperimental PharmacologyOxidative StressMolecular Pharmacology +16

Pharmacokinetics of carboplatin after i.v. administration.

F. Elferink, W J van der Vijgh, I. Klein, +3

PubMed

OncologyPharmacokinetic ModelingFinal Half-lifeMedicineFree Pt +10

Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse.

M. Treskes, Epie Boven, U. Holwerda, +2

PubMed

Formulated Wr2721PharmacotherapyCisplatin DoseToxicological MechanismOxidative Stress +15

7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week.

F A van Acker, S A van Acker, Klaas Kramer, +3

PubMed

InflammationMolecular PharmacologyShort Half-lifeHeart FailureDoxorubicin-induced Cardiotoxicity +12

Monohydroxyethylrutoside, a dose-dependent cardioprotective agent, does not affect the antitumor activity of doxorubicin.

S A van Acker, Epie Boven, Karel K.J. Kuiper, +5

PubMed

InflammationMedicinal ChemistryMg/kg Doxorubicin I.v.Antitumor ActivityLipid Peroxidation +13

Pharmacokinetics and pharmacodynamics of lobaplatin (D-19466) in patients with advanced solid tumors, including patients with impaired renal of liver function.

Jan Welink, E. Boven, Jan B. Vermorken, +2

PubMed

PharmacotherapyLiver FunctionMetronomic ChemotherapyAdvanced Solid TumorsHematological Malignancy +14

Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients.

A.E.C. Korst, M L van der Sterre, H.E. Gall, +3

PubMed

Serum Creatinine LevelsMolecular PharmacologyTherapeutic Drug MonitoringUrologyOncology +10

Frederine, a new and promising protector against doxorubicin-induced cardiotoxicity.

F A van Acker, Epie Boven, Klaas Kramer, +3

PubMed

Lipid PeroxidationCardiovascular PharmacologyPharmacotherapyCardiovascular ToxicityPolyphenolics +17

Cardioprotective properties of O-(beta-hydroxyethyl)-rutosides in doxorubicin-pretreated BALB/c mice.

S A van Acker, Emile E. Voest, D B Beems, +4

PubMed

InflammationMolecular PharmacologyMedicinal ChemistryRight AtriumDoxorubicin Pretreatment +13

The role of biotransformation in anthracycline-induced cardiotoxicity in mice.

Jan de Jong, P.R. Schoofs, A M Snabilié, +2

Journal of Pharmacology and Experimental Therapeutics