W J van der Vijgh

In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.

Godefridus J. Peters, Gilberto Schwartsmann, Jorge Nadal et al. · PubMed · 1990 · 82 citations

Mitochondrial Pyrimidine, Pharmacotherapy, Experimental Pharmacology +18

Pharmacokinetics of carboplatin after i.v. administration.

F. Elferink, W J van der Vijgh, I. Klein et al. · PubMed · 1987 · 68 citations

Oncology, Pharmacokinetic Modeling, Final Half-life +12

Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse.

M. Treskes, Epie Boven, U. Holwerda et al. · PubMed · 1992 · 66 citations

Formulated Wr2721, Pharmacotherapy, Cisplatin Dose +17

7-monohydroxyethylrutoside protects against chronic doxorubicin-induced cardiotoxicity when administered only once per week.

F A van Acker, S A van Acker, Klaas Kramer et al. · PubMed · 2000 · 66 citations

Inflammation, Molecular Pharmacology, Short Half-life +14

Monohydroxyethylrutoside, a dose-dependent cardioprotective agent, does not affect the antitumor activity of doxorubicin.

S A van Acker, Epie Boven, Karel K.J. Kuiper et al. · PubMed · 1997 · 58 citations

Inflammation, Medicinal Chemistry, Mg/kg Doxorubicin I.v. +15