Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275

Gurmeet Kaur, M Stetler-Stevenson, S Sebers, +6

JNCI Journal of the National Cancer Institute

Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy

H.H. Sedlacek, Jörg Czech, Ramachandra Naik, +8

International Journal of Oncology

Chemoprevention StrategyPharmacotherapyNew Synthetic FlavoneTumor BiologyPolyphenolics +16

Tumor-selective prodrug activation by fusion protein-mediated catalysis.

Klaus Bosslet, Jörg Czech, Dieter Hoffmann

PubMed

Drug TargetingOncologyTumor-selective Prodrug ActivationMedicineSelective Tumor Therapy +11

Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold:  A Study Combining Structure-Activity Relationship and X-ray Crystallography

Marc Nazaré, David W. Will, Hans Matter, +10

Journal of Medicinal Chemistry

X-ray CrystallographyDrug TargetMolecular BiologyMedicinal ChemistryProtein X-ray Crystallography +15

Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation

Klaus Bosslet, Jörg Czech, Peter Lorenz, +3

British Journal of Cancer

Functional CharacterisationProtein FunctionMedicineDrug DiscoveryCancer Biology +9

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Aimo Kannt, Sridharan Rajagopal, Sanjay Venkatachalapathi Kadnur, +26

Scientific Reports

Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein–Ligand Complexes

Marc Nazaré, Hans Matter, David W. Will, +7

Angewandte Chemie International Edition

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

Herman Schreuder, A. Liesum, Petra Lönze, +15

Scientific Reports

ANTITUMORAL ACTIVITY OF FLAVONE L-86-8275

Jörg Czech, Dennis Hoffmann, Ramachandra Naik, +1

International Journal of Oncology

Medicinal ChemistryVitro L 86-8275OncologyKinase InhibitorChemoprevention Strategy +13

Discovery of <i>N</i>-[4-(1<i>H</i>-Pyrazolo[3,4-<i>b</i>]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors

Nis Halland, Friedemann Schmidt, Joachim Saas, +8

ACS Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryVirtual ScreeningDrug TargetBiochemistry +13