Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Joe Swift, Irena L. Ivanovska, Amnon Buxboim, +10

Science

Tissue EngineeringEngineeringTissue ElasticityCytoskeletonBiomedical Engineering +19

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

Takamasa Harada, Joe Swift, Jerome Irianto, +7

The Journal of Cell Biology

EngineeringMechanical EngineeringCytoskeletonBiomedical EngineeringStem Cell Migration +18

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

Amnon Buxboim, Joe Swift, Jerome Irianto, +8

Current Biology

MechanobiologyCell-matrix InteractionCell MotilityCell BiomechanicsCytoskeleton +7

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

Matthew Raab, Joe Swift, P.C. Dave P. Dingal, +3

The Journal of Cell Biology

Tissue EngineeringEngineeringMolecular BiologyRearward PolarizationCytoskeleton +24

Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival

Takamasa Harada, Joe Swift, Jerome Irianto, +7

EngineeringMolecular BiologyCytoskeletonBiomedical EngineeringStem Cell Migration +19

Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells

Jae‐Won Shin, Amnon Buxboim, Kyle Spinler, +10

Cell stem cell

Progenitor CellsDevelopmental BiologyCell DivisionMedicineStem Cell Mobilization +10

Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes

Jae‐Won Shin, Joe Swift, Kyle Spinler, +1

Proceedings of the National Academy of Sciences

Platelet GenerationMyosin-ii InhibitionMolecular BiologyCytoskeletonCellular Physiology +20

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia

Kyle Spinler, Jae‐Won Shin, Michele P. Lambert, +1

Blood

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation

Aae Suzuki, Jae‐Won Shin, Yuhuan Wang, +9

PLoS ONE

Platelet GenerationNormal Megakaryocyte PloidyBlood CellPlatelet PathobiologyCell Culture +18

Improving Stem Cell Therapeutics with Mechanobiology

Jae‐Won Shin, David Mooney

Cell stem cell

Regenerative MedicineTissue EngineeringMechanobiologyEngineeringCellular Therapies +10