Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, +303

Science

Viral DiagnosticsCovid-19 PandemicViral PathogenesisImmunologyMolecular Biology +10

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

Roland Hjerpe, John S. Bett, Matthew J. Keuss, +14

Cell

Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal <scp>PINK</scp> 1‐dependent phosphorylation and activation

Agne Kazlauskaite, R.J. Martinez-Torres, Scott Wilkie, +14

EMBO Reports

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

Suzannah J. Rihn, Andres Merits, Siddharth Bakshi, +79

PLoS Biology

EngineeringGeneticsImmunologyViral PathogenesisCovid-19 Epidemiology +17

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Akihito Ohta, Frances‐Rose Schumacher, Youcef Mehellou, +6

Biochemical Journal

Hypertension Syndrome InteractsGeneticsImmunologyDisease-causing MutationsBlood Pressure +14

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

Yosua Adi Kristariyanto, S.A. Abdul Rehman, David G. Campbell, +4

Molecular Cell

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Agne Kazlauskaite, Van Kelly, Clare Johnson, +8

Open Biology

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

Sara Priego Moreno, Axel Knebel, Clare Johnson, +4

Nature Cell Biology

ChromatinGenome InstabilityCell DivisionNatural SciencesMolecular Biology +6

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Atul Kumar, Viduth K. Chaugule, Tara Condos, +7

Nature Structural & Molecular Biology

Protein FunctionBiochemistryNatural SciencesRbr Ligase ActivityMolecular Biology +3

Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Frances‐Rose Schumacher, Keith Siew, Jinwei Zhang, +12

EMBO Molecular Medicine