Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites

Godefridus J. Peters, C.J. van Groeningen, E. Laurensse, +3

Cancer Chemotherapy and Pharmacology

MedicinePhysiologyRenal InflammationTissue LevelsRenal Pathophysiology +4

In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.

Godefridus J. Peters, Gilberto Schwartsmann, Jorge Nadal, +4

PubMed

Mitochondrial PyrimidinePharmacotherapyExperimental PharmacologyOxidative StressMolecular Pharmacology +16

Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390)

Godefridus J. Peters, S Sharma, E. Laurensse, +1

Investigational New Drugs

BiosynthesisBiochemistryNatural SciencesDrug DiscoveryBiochemical Genetics +7

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil

Jerry van Dijk, E. Laurensse, CJ van Groeningen, +4

British Journal of Cancer

Medicinal ChemistryPharmaceutical ScienceBiochemistryNatural SciencesUridine 'Rescue +6

Reversal of 5-Fluorouracil-Induced Myelosuppression by Prolonged Administration of High-Dose Uridine

C.J. van Groeningen, Godefridus J. Peters, Alejandro Leyva, +2

JNCI Journal of the National Cancer Institute

Therapeutic Drug MonitoringMedicineHematologyHigh-dose UridineNine Patients +8

Clinical and Pharmacologic Study of Orally Administrated Uridine

G. J. Van Groeningen, Godefridus J. Peters, Jorge Nadal, +2

JNCI Journal of the National Cancer Institute

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes

BJM Braakhuis, EA de Bruijn, E. Laurensse, +2

British Journal of Cancer

5-Fluorouracil Resistant HeadMedicinePharmacologyPathology5-Fluorouracil Metabolising Enzymes +10

Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing

Godefridus J. Peters, I Kraal, E. Laurensse, +2

Journal of Chromatography B Biomedical Sciences and Applications

Chemical EngineeringEngineeringSeparation ScienceBioanalysisSelective Separation +9

DUP 785 (NSC 368390): Schedule-dependency of growth-inhibitory and antipyrimidine effects

Gilberto Schwartsmann, Godefridus J. Peters, E. Laurensse, +4

Biochemical Pharmacology

Molecular PharmacologyBiochemistryMedicineDup 785Mechanism Of Action +5

Separation of several 5-Fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-Fluorouracil-nucleotide sugars

Godefridus J. Peters, E. Laurensse, J. Lankelma, +2

European Journal of Cancer and Clinical Oncology

Medicinal ChemistryBiosynthesis5-Fluorouracil-nucleotide SugarsBiochemistryNatural Sciences +5