M. Isabel Chiu

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

M. Isabel Chiu, Howard R. Katz, Vivian Berlin · Proceedings of the National Academy of Sciences · 1994 · 477 citations · Full text

Molecular Regulation, Immunology, Molecular Biology +17

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

Elizabeth Buck, Prafulla C. Gokhale, Susan Koujak et al. · Molecular Cancer Therapeutics · 2010 · 216 citations

Igf-1r Inhibition, Tumor Biology, Signal Transduction +14

Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients

Lorena Lerner, Teresa G. Hayes, Nianjun Tao et al. · Journal of Cachexia Sarcopenia and Muscle · 2015 · 189 citations · Full text

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Lorena Lerner, Julie Tao, Qing Liu et al. · Journal of Cachexia Sarcopenia and Muscle · 2015 · 174 citations · Full text

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas

Yinghui Zhou, William M. Rideout, Tong Zi et al. · Nature Biotechnology · 2009 · 86 citations

Tumor Biology, Medicine, Cancer Cell Biology +9