Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

Roberta Montanari, Fulvio Saccoccia, Elena Scotti, +12

Journal of Medicinal Chemistry

Crystal StructureOther LigandsBiochemistryFunctional SelectivityDrug Design +13

The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice

Cynthia Hong, Stephanie Marshall, Allison L. McDaniel, +14

Cell Metabolism

Knockout MouseMolecular RegulationImmunologyVascular BiologyMedicine +2

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

Elena Scotti, Martino Calamai, Chris N. Goulbourne, +11

Molecular and Cellular Biology

Proteinlipid InteractionClathrin-independent EndocytosisLdlr DegradationPathologyMolecular Biology +16

Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists

Elena Scotti, Cynthia Hong, Yuko Yoshinaga, +8

Molecular and Cellular Biology

Ldlr DegradationGeneticsFatty Liver DiseaseMetabolic SyndromeTranscriptional Regulation +16

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Li Zhang, Ming Xu, Elena Scotti, +2

Journal of Lipid Research

Insights in the regulation of cholesterol 7α-hydroxylase gene reveal a target for modulating bile acid synthesis

Nico Mitro, Cristina Godio, Emma De Fabiani, +6

Hepatology

Exploring the microbiome in health and disease

Elena Scotti, Stéphanie Boué, Giuseppe Lo Sasso, +8

Toxicology Research and Application

Microbiota FunctionDysbiosisMicrobial DiseaseHost-microbe InteractionsMicrobiota +13

Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis

G. Pochetti, Nico Mitro, Antonio Lavecchia, +13

Journal of Medicinal Chemistry

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study

Filippo Zanetti, Bjoern Titz, Alain Sewer, +16

Food and Chemical Toxicology

Systems Toxicology ApproachCigarette SmokePeriodontal DiseasesTobacco ControlRisk Tobacco Product +14

The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product

Marco van der Toorn, Alain Sewer, Diego Marescotti, +15

Toxicology in Vitro

Tpm ExposureCmrtp TpmLung InflammationImmunologyAir Quality +22