William P. Lynch

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

Lymphoid Neoplasia, Autoimmune Disease, Immunology +6

Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons

Jitka Ourednik, Václav Ourednik, William P. Lynch et al. · Nature Biotechnology · 2002 · 497 citations

Neuroregeneration, Adult Stem Cell, Neural Stem Cell +9

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Dorit Trudler, Sara Sanz‐Blasco, Yvonne S. Eisele et al. · Journal of Neuroscience · 2021 · 99 citations · Full text

Smooth muscle caldesmon is an extended flexible monomeric protein in solution that can readily undergo reversible intra- and intermolecular sulfhydryl cross-linking. A mechanism for caldesmon's F-actin bundling activity.

William P. Lynch, V M Riseman, Anthony Bretscher · Journal of Biological Chemistry · 1987 · 98 citations · Full text

F-actin Bundling Activity, Intermolecular Sulfhydryl Cross-linking, Protein Assembly +16

Murine retrovirus-induced spongiform encephalopathy: Productive infection of microglia and cerebellar neurons in accelerated CNS disease

William P. Lynch, Stephanie Czub, Frank J. McAtee et al. · Neuron · 1991 · 77 citations · Full text

Productive Infection, Neurological Disorder, Neurovirology +12