Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor

Karen Ring, Leslie M. Tong, Maureen E. Balestra, +7

Cell stem cell

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyHealth SciencesMedicine +12

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

Chengzhong Wang, Ramsey Najm, Qin Xu, +10

Nature Medicine

Human Ipsc-derived NeuronsMolecular NeuroscienceBiochemistrySmall-molecule Structure CorrectorNeuroprotection +7

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

Shengjun Chang, Ran Tian, R. Dennis Miranda, +3

Proceedings of the National Academy of Sciences

Amino AcidsMitochondrial DysfunctionLipid PeroxidationCell DeathMolecular Biology +16

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

Hung-Kai Chen, Zhaoping Liu, Anke Meyer‐Franke, +15

Journal of Biological Chemistry

Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells

Helen Fong, Chengzhong Wang, Johanna Knöferle, +12

Stem Cell Reports

Intron-3 Retention/Splicing Controls Neuronal Expression of Apolipoprotein E in the CNS

Qin Xu, David Walker, Aubrey Bernardo, +3

Journal of Neuroscience

Differences in Receptor Binding of LDL Subfractions

Hannia Campos, K S Arnold, Maureen E. Balestra, +2

Arteriosclerosis Thrombosis and Vascular Biology

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

Jens Brodbeck, Jim McGuire, Zhaoping Liu, +16

Journal of Biological Chemistry

Proteinlipid InteractionStructure-dependent ImpairmentDetrimental EffectsMolecular BiologyAmyloid Precursor Protein +20

Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease

Alice Taubes, Phil Nova, Kelly A. Zalocusky, +23

Nature Aging

Neuroimaging BiomarkersNeurodegenerative DiseasesAlzheimer's DiseaseMedicineReal-world Evidence +10

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

Jens Brodbeck, Maureen E. Balestra, Ann M. Saunders, +3

Proceedings of the National Academy of Sciences