Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

Karen S. SantaCruz, Jada Lewis, Jennifer Paulson, +15

Science

Neurochemical BiomarkersSocial SciencesAlzheimer's DiseaseNeurofibrillary TanglesMemory +16

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

Martin Ramsden, Linda Kotilinek, Colleen L. Forster, +9

Journal of Neuroscience

Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy

Zdenek Berger, Hanno M. Roder, Amanda Hanna, +11

Journal of Neuroscience

Molecular BiologyPathological Tau SpeciesSocial SciencesAlzheimer's DiseaseNeurofibrillary Tangles +15

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Yong‐Jie Zhang, Tania F. Gendron, Mark Ebbert, +20

Nature Medicine

Amyotrophic Lateral SclerosisAlzheimer's DiseaseDementiaProtein TranslationStress Granule Dynamics +7

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Yong‐Jie Zhang, Tania F. Gendron, Jonathan C. Grima, +32

Nature Neuroscience

Protein FunctionSignal TransductionNucleocytoplasmic Transport ProteinsMedicineNatural Sciences +9

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Heather L. Melrose, Justus C. Dächsel, Bahareh Behrouz, +23

Neurobiology of Disease

Knockout MouseNeurodegenerative DiseasesSignal TransductionMolecular NeuroscienceMolecular Physiology +8

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Mei Yue, Kelly M. Hinkle, Paul Davies, +17

Neurobiology of Disease

Progressive Dopaminergic AlterationsMitophagyMitochondrial AbnormalitiesMolecular PhysiologyMitochondrial Function +6

Poly(GP) proteins are a useful pharmacodynamic marker for <i>C9ORF72</i> -associated amyotrophic lateral sclerosis

Tania F. Gendron, Jeannie Chew, Jeannette N. Stankowski, +75

Science Translational Medicine

Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

Chad A. Dickey, Mei Yue, Wen-Lang Lin, +13

Journal of Neuroscience

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia

Mercedes Prudencio, Jack Humphrey, Sarah Pickles, +49

Journal of Clinical Investigation

Corticobasal DegenerationPathologyNeurochemical BiomarkersAlzheimer's DiseaseNeurology +16