Toward a Neuro-Cognitive Animal Model of the Cognitive Symptoms of Schizophrenia: Disruption of Cortical Cholinergic Neurotransmission Following Repeated Amphetamine Exposure in Attentional Task-Performing, but Not Non-Performing, Rats

Rouba Kozak, Vicente Martínez, Damon Young, +3

Neuropsychopharmacology

Cognitive ScienceCognitive SymptomsPsychiatryAttentional Task-performingMedicine +11

A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats

Ajeesh Koshy Cherian, Howard J. Gritton, David E. Johnson, +3

Neuropharmacology

Kat IiNicotine-evoked Glutamatergic ActivityNeurophysiologyMedicineNicotine +8

Nicotinic receptor subtypes differentially modulate glutamate release in the dorsal medial striatum

William M. Howe, Damon Young, George Bekheet, +1

Neurochemistry International

Health SciencesNeurophysiologySynaptic TransmissionPhysiologyNicotinic Receptor Subtypes +10

D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects

Damon Young, Michael Popiolek, Patrick Trapa, +4

ACS Chemical Neuroscience

Motor ControlStriatal Dopaminergic LossNeurologyMotor DisorderHealth Sciences +14

<i>In Vivo</i> Modulation of Hippocampal Excitability by M4 Muscarinic Acetylcholine Receptor Activator: Implications for Treatment of Alzheimer’s Disease and Schizophrenic Patients

Michael Popiolek, Yael Mandelblat-Cerf, Damon Young, +6

ACS Chemical Neuroscience

Schizophrenic PatientsNeurotransmitterNeurochemical BiomarkersAbnormal Hippocampal ActivitySynaptic Signaling +15

Increased striatal dopamine synthesis is associated with decreased tissue levels of tyrosine

Rodolfo Bongiovanni, Damon Young, Erica Newbould, +1

Brain Research

Striatal Dopamine SynthesisMedicineNeurotransmitterNeuropharmacologyNeuroscience +5

Clozapine-induced dopamine release in the medial prefrontal cortex is augmented by a moderate concentration of locally administered tyrosine but attenuated by high tyrosine concentrations or by tyrosine depletion

George E. Jaskiw, Bobbi Kirkbride, Erica Newbould, +3

Psychopharmacology

Psychoactive DrugPsychiatryClozapine-induced Dopamine ReleasePsychopharmacologySchizophrenia +9

α5 nAChR modulation of the prefrontal cortex makes attention resilient

William M. Howe, Julie L. Brooks, Patrick L. Tierney, +8

Brain Structure and Function

Neurobiological MechanismCognitive Scienceα5 Nachr ModulationBrain FunctionMedicine +10

Cross-site strain comparison of pharmacological deficits in the touchscreen visual discrimination test

Eric G. Mohler, Zhiyong Ding, Lynne E. Rueter, +3

Psychopharmacology

Physiological OpticNeurophysiologyMedicineNeuropharmacologyDrug Test +7

MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function

William M. Howe, Patrick L. Tierney, Damon Young, +2

Psychopharmacology

NeuropsychologyPsychiatryBrain FunctionBehavioral NeuroscienceDevelopmental Cognitive Neuroscience +10