A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies

Gabriele Schaefer, Lauric Haber, Lisa Crocker, +20

Cancer Cell

Immunocytochemical TechniqueAllergyAutoimmune DiseaseImmunologyAntibody Screening +7

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

Yingnan Zhang, Charles Eigenbrot, Lijuan Zhou, +10

Journal of Biological Chemistry

Signal TransductionBiochemistryPeptide LibraryImmunologySmall Peptide +4

Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies

Aditya A. Wakankar, Ronald T. Borchardt, Charles Eigenbrot, +4

Biochemistry

Immunocytochemical TechniqueImmunologyGlycobiologyPathologyImmunotherapy +17

Lead identification of novel and selective TYK2 inhibitors

Jun Liang, Vickie Tsui, Anne van Abbema, +29

European Journal of Medicinal Chemistry

Medicinal ChemistryHit IdentificationBiochemistryMedicineNatural Sciences +4

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Jun Liang, Anne van Abbema, Mercedesz Balázs, +33

Journal of Medicinal Chemistry

Pharmaceutical ResearchImmunologyLead IdentificationPharmacotherapyPre-clinical Pharmacology +22

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Janusz J. Kulagowski, Wade Blair, Richard J. Bull, +27

Journal of Medicinal Chemistry

RheumatologyMedicinal ChemistryDrug TargetBiochemistryMedicine +13

Conformational Lability in Serine Protease Active Sites: Structures of Hepatocyte Growth Factor Activator (HGFA) Alone and with the Inhibitory Domain from HGFA Inhibitor-1B

Steven Shia, Jennifer L. Stamos, Daniel Kirchhofer, +6

Journal of Molecular Biology

Protein ChemistryProtein FunctionProtein AssemblyBiochemistryProtein Folding +8

Structural insight into distinct mechanisms of protease inhibition by antibodies

Yan Wu, Charles Eigenbrot, Wei‐Ching Liang, +6

Proceedings of the National Academy of Sciences

Active Site InhibitorsImmunologyProteasomeMolecular BiologyAntigen Processing +14

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

Yingnan Zhang, Mark Ultsch, Nicholas J. Skelton, +13

Nature Structural & Molecular Biology

Signal TransductionBiochemistryNatural SciencesPeptide EngineeringPeptide Library +6

Identification of <i>C</i>-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Mark Zak, Christopher A. Hurley, Stuart I. Ward, +44

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +17