Glial Cell Line-Derived Neurotrophic Factor Induces Barrier Function of Endothelial Cells Forming the Blood–Brain Barrier

Y Igarashi, Hiroyuki Utsumi, Hideki Chiba, +8

Biochemical and Biophysical Research Communications

Glial BiologyEndothelial CellsBlood–brain BarrierNeurophysiologyVascular Biology +8

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita, +27

Bioorganic & Medicinal Chemistry

BiochemistryMedicineRational Drug DesignType 2Pharmacological Agent +5

Expression of GFRα-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB

Hiroyuki Utsumi, Hideki Chiba, Yasuhiro Kamimura, +5

American Journal of Physiology-Cell Physiology

Porcine Endothelial CellsBrain DevelopmentSocial SciencesRat BrainCerebral Vascular Regulation +22

Expression of Receptors for Glial Cell Line-derived Neurotrophic Factor (GDNF) and Neurturin in the Inner Blood-retinal Barrier of Rats.

Y Igarashi, Hideki Chiba, Hiroyuki Utsumi, +8

Cell Structure and Function

Automated image analysis of a glomerular injury marker desmin in spontaneously diabetic Torii rats treated with losartan

Tetsuhiro Kakimoto, Kinya Okada, Yoshihiro Hirohashi, +8

Journal of Endocrinology

GlomerulonephritisUrologyImage AnalysisRenal FunctionOphthalmology +12

The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice

Sayaka Fukuda-Tsuru, Tetsuhiro Kakimoto, Hiroyuki Utsumi, +2

European Journal of Pharmacology

ObesityMetabolic SyndromeHigh-fat Diet-induced ObesityEnergy HomeostasisBiochemistry +8

IL-17–Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions

Yasuhiro Maeda, Noriyasu Seki, Hirotoshi Kataoka, +5

The Journal of Immunology

Lymphocyte DevelopmentImmunodeficienciesImmunologyImmune RegulationImmunologic Mechanism +19

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells

Kyoko Shimano, Yasuhiro Maeda, Hirotoshi Kataoka, +5

PLoS ONE

InflammationCytokineCd4+cd45rbhigh T CellsChronic ColitisAutoimmune Disease +12

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction

Itsuko Baba, Yasuhiro Egi, Hiroyuki Utsumi, +2

Molecular Medicine Reports

Renal PathologyRenal InflammationPathologyRenal FibrosisCytoskeleton +24

S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1

Yasuhiro Maeda, Hideki Yagi, Kana Takemoto, +5

International Immunology