Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

Masami Suganuma, Hirota Fujiki, Hiroko Suguri, +7

Proceedings of the National Academy of Sciences

Black SpongeOkadaic AcidMedicineCutaneous BiologyPharmacology +11

Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

H Fujiki, Masami Mori, M Nakayasu, +3

Proceedings of the National Academy of Sciences

Medicinal ChemistryBiosynthesisDihydroteleocidin BTumor-promoting ActivityBiochemistry +13

Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

Hiromi Hakii, Hirota Fujiki, Masami Suganuma, +5

Journal of Cancer Research and Clinical Oncology

Tumor BiologySignal TransductionMalignant DiseaseOncogenic AgentHistamine Secretagogue +7

Quantitative measurement of melanin as tyrosine equivalents and as weight of purified melanin.

Atsushi Oikawa, M Nakayasu

PubMed

Purified MelaninTyrosine EquivalentsMedicinePhysiologyClinical Chemistry +3

Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.

Hiroshi Shima, M Nakayasu, S. Aonuma, +2

Proceedings of the National Academy of Sciences

Mixed-phenotype Acute LeukemiaImmunologyPathologyTumor BiologyMyeloid Neoplasia +14

Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid.

Tomoko Tahira, Yukihito Ishizaka, Fumiaki Itoh, +3

PubMed

Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase.

M Nakayasu, Hiroshi Shima, S. Aonuma, +3

Proceedings of the National Academy of Sciences

Molecular BiologyCell CultureCell ProliferationCell GrowthNih 3T3 +14

Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.

Hiroshi Shima, Hideki Tohda, Seiichi Aonuma, +4

Proceedings of the National Academy of Sciences

GeneticsMolecular GeneticsOkadaic Acid-resistant VariantsType 1Protein Expression +16

Induction of differentiation of human and murine myeloid leukemia cells in culture by tunicamycin.

M Nakayasu, M Terada, Gakuzo Tamura, +1

Proceedings of the National Academy of Sciences

ImmunologyCellular PhysiologyTumor BiologyMyeloid NeoplasiaHematological Malignancy +14

The third class of new tumor promoters, polyacetates (debromoaplysiatoxin and aplysiatoxin), can differentiate biological actions relevant to tumor promoters.

Hirota Fujiki, Masami Suganuma, M Nakayasu, +3

PubMed

Potent Tumor PromoterPathologyCell DeathHl-60 CellsDermatology +14