Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

Hiromi Hakii, Hirota Fujiki, Masami Suganuma, +5

Journal of Cancer Research and Clinical Oncology

Tumor BiologySignal TransductionMalignant DiseaseOncogenic AgentHistamine Secretagogue +7

Palytoxin is a non-12-<i>O</i>-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis

Hirota Fujiki, Masami Suganuma, Michie Nakayasu, +4

Carcinogenesis

A two-stage mouse skin carcinogenesis study of lyngbyatoxin A

Hirota Fujiki, Masami Suganuma, Hiromi Hakii, +4

Journal of Cancer Research and Clinical Oncology

Cutaneous BiologyPhotocarcinogenesisPathologyCarcinogenesis StudyDermatology +4

Inhibition of tumor promotion by flavonoids.

Hirota Fujiki, Takahiko Horiuchi, Kensuke Yamashita, +6

PubMed

Chemoprevention StrategyMedicineCancer Cell BiologyAnti-cancer AgentTumor Promotion +3

A blue-green alga from Okinawa contains aplysiatoxins, the third class of tumor promoters.

Hirota Fujiki, Kazuyuki Ikegami, Hiromi Hakii, +5

PubMed

PathologyDermatologyTumor BiologyToxicological MechanismBiosynthesis +18

Tumor promoting activities of new synthetic analogues of teleocidin.

Hirota Fujiki, Masami Suganuma, Hiromi Hakii, +6

Proceedings of the Japan Academy Series B

Medicinal ChemistryNew Synthetic AnaloguesOncogenic AgentMedicineAnti-cancer Agent +2

Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters

Kazuo Ohuchi, Noriyasu Hirasawa, Chikako Takahashi, +7

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Non-tpa-type Tumor PromotersMolecular PhysiologySignal TransductionMedicineMast Cell Disorder +5

Binding studies of [H]Lyngbyatoxin A and [H]debromoaplysiatoxin to the phorbol ester receptor in a mouse epidermal particulate fraction

Richard E. Moore, Gregory M. L. Patterson, Michael Entzeroth, +5

Carcinogenesis

Signal TransductionCatalytic Triton-proton ExchangeBiochemistryPhorbol Ester ReceptorLyngbyatoxin A +11

Modulation of phorbol ester receptors in mouse skin by application of quercetin.

Takahiko Horiuchi, Hirota Fujiki, Hiromi Hakii, +3

PubMed

Chemoprevention StrategyTopical ApplicationPharmacotherapyDermatologyExperimental Pharmacology +14

Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity.

Takahiko Horiuchi, Hirota Fujiki, Masami Suganuma, +7

PubMed

BiologyFree Hydroxyl GroupPhytoalexinBiosynthesisBioorganic Chemistry +11