Ecaterina E. Dumbrava

Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

Timothy A. Yap, Naval Daver, Mikhila Mahendra et al. · Nature Medicine · 2023 · 335 citations · Full text

Hematological Malignancy, Oncology, Biochemistry +8

Phase 2 study of pembrolizumab in patients with advanced rare cancers

Aung Naing, Funda Meric‐Bernstam, Bettzy Stephen et al. · Journal for ImmunoTherapy of Cancer · 2020 · 127 citations · Full text

Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring <i>CCNE1</i> Amplification

Siqing Fu, Shuyang Yao, Yuan Yuan et al. · Journal of Clinical Oncology · 2022 · 84 citations · Full text

First-in-human study of PC14586, a small molecule structural corrector of Y220C mutant p53, in patients with advanced solid tumors harboring a <i>TP53</i> Y220C mutation.

Ecaterina E. Dumbrava, Melissa L. Johnson, Anthony W. Tolcher et al. · Journal of Clinical Oncology · 2022 · 77 citations

Spontaneous Mutation, Molecular Biology, Pathology +17

Phase I trial of IACS-010759 (IACS), a potent, selective inhibitor of complex I of the mitochondrial electron transport chain, in patients (pts) with advanced solid tumors.

Timothy A. Yap, Jordi Rodón, Sarina A. Piha‐Paul et al. · Journal of Clinical Oncology · 2019 · 66 citations

Pathology, Advanced Solid Tumors, Tumor Biology +17