Martin O’Rourke

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 135 citations · Full text

Medicine, Oncology, Pharmacology +15

A Novel FK506-Like Binding Protein Interacts with the Glucocorticoid Receptor and Regulates Steroid Receptor Signaling

Hayley D. McKeen, Kerry McAlpine, Andrea Valentine et al. · Endocrinology · 2008 · 73 citations

Life Sciences, Biochemistry, Molecular Biology +17

FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism

Andrea Valentine, Martin O’Rourke, Anita Yakkundi et al. · Clinical Cancer Research · 2011 · 70 citations · Full text

Medicine, Oncology, Pharmacology +14

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

Lana McClements, Stephanie Annett, Anita Yakkundi et al. · BMC Cancer · 2019 · 68 citations · Full text

Medicine, Oncology, Pharmacology +17

Novel bradykinins and their precursor cDNAs from European yellow‐bellied toad (<i>Bombina variegata</i>) skin

Tianbao Chen, David F. Orr, Anthony J. Bjourson et al. · European Journal of Biochemistry · 2002 · 57 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10