Derek Pacheco

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

Peter S. Brzović, Clemens C. Heikaus, Leonid Kisselev et al. · Molecular Cell · 2011 · 217 citations · Full text

Protein Function, Protein Expression, Natural Sciences +8

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

Lisa M. Tuttle, Derek Pacheco, Linda Warfield et al. · Cell Reports · 2018 · 155 citations · Full text

Protein Assembly, Multiple Abds, Molecular Biology +17

A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

Linda Warfield, Lisa M. Tuttle, Derek Pacheco et al. · Proceedings of the National Academy of Sciences · 2014 · 111 citations · Full text

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA

Rafał Donczew, Linda Warfield, Derek Pacheco et al. · eLife · 2020 · 107 citations · Full text

Chromatin, Systems Biology, Functional Genomics +15

Mechanism of Mediator Recruitment by Tandem Gcn4 Activation Domains and Three Gal11 Activator-Binding Domains

Eric Herbig, Linda Warfield, Lisa Fish et al. · Molecular and Cellular Biology · 2010 · 95 citations · Full text

Molecular Regulation, Gal11 Independence, Molecular Biology +19