Steven A. Middleton

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

Oded Livnah, E.A. Stura, Steven A. Middleton et al. · Science · 1999 · 596 citations

Crystal Structure, Crystallographic Evidence, Actual Dimer Configuration +20

Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

Oded Livnah, E.A. Stura, Dana L. Johnson et al. · Science · 1996 · 592 citations

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

Isabelle Ray‐Coquard, Jean‐Yves Blay, Antoîne Italiano et al. · The Lancet Oncology · 2012 · 553 citations

Mdm2 Antagonist Rg7112, Medicine, Pharmacology +9

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

Anthony W. Tolcher, Wells A. Messersmith, Stanislaw M. Mikulski et al. · Journal of Clinical Oncology · 2012 · 277 citations · Full text

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Ronghui Lin, Sigmond G. Johnson, Peter J. Connolly et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 126 citations · Full text

Medicinal Chemistry, Medicine, Pharmacological Agent +7