Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

Oded Livnah, E.A. Stura, Steven A. Middleton, +3

Science

Crystal StructureCrystallographic EvidenceActual Dimer ConfigurationCellular PhysiologySignaling Pathway +18

Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

Oded Livnah, E.A. Stura, Dana L. Johnson, +6

Science

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

Isabelle Ray‐Coquard, Jean‐Yves Blay, Antoîne Italiano, +12

The Lancet Oncology

Mdm2 Antagonist Rg7112MedicinePharmacologyPathologyAnti-cancer Agent +7

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

Anthony W. Tolcher, Wells A. Messersmith, Stanislaw M. Mikulski, +17

Journal of Clinical Oncology

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Ronghui Lin, Sigmond G. Johnson, Peter J. Connolly, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentTyrosine Kinase InhibitorsPharmacotherapy +5

1-Acyl-1<i>H</i>-[1,2,4]triazole-3,5-diamine Analogues as Novel and Potent Anticancer Cyclin-Dependent Kinase Inhibitors:  Synthesis and Evaluation of Biological Activities

Ronghui Lin, Peter J. Connolly, Shenlin Huang, +9

Journal of Medicinal Chemistry

Selective Cdk1Medicinal ChemistryRepresentative Compound 3BMedicinePharmacological Agent +11

The <i>In vitro</i> and <i>In vivo</i> Effects of JNJ-7706621: A Dual Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases

Stuart L. Emanuel, Catherine A. Rugg, Robert H. Gruninger, +9

Cancer Research

Dual InhibitorCell DeathTotal Cumulative DoseCell CycleCancer Biology +20

Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor

Shenlin Huang, Ronghui Lin, Yang Yu, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHeterocyclicBiochemistryMedicineNatural Sciences +6

Identification of a 13 Amino Acid Peptide Mimetic of Erythropoietin and Description of Amino Acids Critical for the Mimetic Activity of EMP1

Dana L. Johnson, Francis X. Farrell, Francis P. Barbone, +12

Biochemistry

Mimetic ActivityProtein FunctionBiochemistryG Protein-coupled ReceptorNatural Sciences +12

Synthesis and Identification of [1,3,5]Triazine-pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors

Gee‐Hong Kuo, A. DeAngelis, Stuart L. Emanuel, +10

Journal of Medicinal Chemistry

Combinatorial ChemistryOrganic ChemistryPharmacotherapyNew SeriesHeterocycle Chemistry +16