Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

Maya A. Farha, Alexander A. C. Leung, Edward W. Sewell, +7

ACS Chemical Biology

Antimicrobial ChemotherapyAntibiotic ResistancePharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +23

Lesions in Teichoic Acid Biosynthesis in <i>Staphylococcus aureus</i> Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway

Michael A. D’Elia, Mark P. Pereira, Yu Seon Chung, +6

Journal of Bacteriology

Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in <i>Bacillus subtilis</i>

Michael A. D’Elia, Kathryn Millar, Terry J. Beveridge, +1

Journal of Bacteriology

Wall Teichoic AcidBiochemistryVirulence FactorBacteriologyEssential Phenotype +7

Are essential genes really essential?

Michael A. D’Elia, Mark P. Pereira, Eric D. Brown

Trends in Microbiology

Systems BiologyGeneticsGene StructureAre Essential GenesMolecular Genetics +6

Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis

Michael A. D’Elia, Kathryn Millar, Amit P. Bhavsar, +5

Chemistry & Biology

BiosynthesisBiochemistryBacteriologyDiverse ProcessesTeichoic Acid Genetics +4

The <i>N</i> -Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in <i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>

Michael A. D’Elia, James A. Henderson, Terry J. Beveridge, +2

Journal of Bacteriology

Studies of the Genetics, Function, and Kinetic Mechanism of TagE, the Wall Teichoic Acid Glycosyltransferase in Bacillus subtilis 168

Sarah E. Allison, Michael A. D’Elia, Sharif Arar, +2

Journal of Biological Chemistry

Duplication of Teichoic Acid Biosynthetic Genes in <i>Staphylococcus aureus</i> Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases

Mark P. Pereira, Michael A. D’Elia, Justyna Troczynska, +1

Journal of Bacteriology

Wall Teichoic AcidEngineeringFunctionally Redundant PolyBacteriologyBacteriophage +14

The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III

Mark P. Pereira, Michael A. D’Elia, Kalinka Koteva, +3

ChemBioChem

Lipid AnalysisBiosynthesisBioorganic ChemistryEngineeringBiochemistry +11

Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: Examination of structural basis for kinetic mechanism

D.H. Fong, V. Yim, Michael A. D’Elia, +2

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Crystal StructureBiochemistryNatural SciencesEnzyme CatalysisStaphylococcus Aureus +5