Edward W. Sewell

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

Maya A. Farha, Alexander A. C. Leung, Edward W. Sewell et al. · ACS Chemical Biology · 2012 · 210 citations · Full text

Antimicrobial Chemotherapy, Antibiotic Resistance, Pharmaceutical Chemistry +25

Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis

Andrew L. Lovering, Leo Lin, Edward W. Sewell et al. · Nature Structural & Molecular Biology · 2010 · 47 citations

Biochemistry, Enzyme Catalysis, Structure-function Enzyme Kinetics +5

Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites

Maya A. Farha, Kalinka Koteva, Robert T. Gale et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 26 citations

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +7

Reconstituting poly(glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates

Robert T. Gale, Edward W. Sewell, Teresa A. Garrett et al. · Chemical Science · 2014 · 17 citations

Engineering, Biomimetic Materials, Glycerol Phosphate +19

The Wall Teichoic Acid Polymerase TagF Is Non-processive in Vitro and Amenable to Study Using Steady State Kinetic Analysis

Edward W. Sewell, Mark P. Pereira, Eric D. Brown · Journal of Biological Chemistry · 2009 · 16 citations · Full text

Bioorganic Chemistry, Wall Teichoic, Chemical Biology +18