Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors

Wenchao Lu, Jun Wang, Yong Li, +18

European Journal of Medicinal Chemistry

BiochemistryPolymer-drug ConjugateMedicineBioconjugationBiological Evaluation +4

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

Shijie Fan, Liyan Yue, Wei Wan, +24

Angewandte Chemie International Edition

Long Noncoding RNA Linc00632 Inhibits Interleukin-13-Induced Inflammatory Cytokine and Mucus Production in Nasal Epithelial Cells

Liyan Yue, Xiaoyan Yin, Hao Fang, +4

Journal of Innate Immunity

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyInnate Immunity +14

Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues

Hao Jiang, Jing Xing, Chen Wang, +14

Organic & Biomolecular Chemistry

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

Zhongya Sun, Hao Zhang, Yuanyuan Zhang, +23

Advanced Science

Covalent InhibitorsMolecular BiologyChemical BiologyTumor BiologyMedicinal Chemistry +17

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay

Tian Lu, Junchi Hu, Wenchao Lu, +10

Acta Pharmacologica Sinica

Small Molecule InhibitorsDrug TargetBiochemistrySmarca2 BromodomainMedicine +9

Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening

Yuan Xu, Liyan Yue, Yulan Wang, +10

Journal of Chemical Information and Modeling

Drug TargetDocking-based Virtual ScreeningSystems PharmacologyMolecular PharmacologyMedicinal Chemistry +19

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors

Wenchao Lu, Huan Xiong, Yu Chen, +18

Bioorganic & Medicinal Chemistry

Cannabis UseMedicinal ChemistryThiobarbituric DerivativesFunctional SelectivityPharmacology +7

Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin–mixed lineage leukaemia interface

Lianchun Li, Ran Zhou, Heji Geng, +8

Bioorganic & Medicinal Chemistry Letters

Antimicrobial Drug DiscoveryBiochemistryAntibioticsMedicineAntimicrobial Chemotherapy +7

Identification of novel small-molecule inhibitors targeting menin–MLL interaction, repurposing the antidiarrheal loperamide

Liyan Yue, Juanjuan Du, Fei Ye, +12

Organic & Biomolecular Chemistry

Drug TargetMolecular BiologyPeptide ScienceNovel Small-molecule InhibitorsChemical Biology +19