Isao Kaneko

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

Yoshio Tsujita, Masao Kuroda, Yoko Shimada et al. · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1986 · 375 citations

Life Sciences, Biochemistry, Pharmacology +14

In vivo conversion of racemized β‐amyloid ([<scp>D</scp>‐Ser²⁶]Aβ1–40) to truncated and toxic fragments ([<scp>D</scp>‐Ser²⁶]Aβ25–35/40) and fragment presence in the brains of Alzheimer's patients

Takekazu Kubo, Satoko Nishimura, Yoshihiro Kumagae et al. · Journal of Neuroscience Research · 2002 · 245 citations

Life Sciences, Biochemistry, Neuroscience +17

Suppression of Mitochondrial Succinate Dehydrogenase, a Primary Target of β‐Amyloid, and Its Derivative Racemized at Ser Residue

Isao Kaneko, Noriko Yamada, Yuko Sakuraba et al. · Journal of Neurochemistry · 1995 · 141 citations

Life Sciences, Biochemistry, Neuroscience +17

Complestain, a potent anti-complement substance produced by Streptomyces lavendulae. I. Fermentation, isolation and biological characterization.

Isao Kaneko, KATUO KAMOSHIDA, Shuji Takahashi · The Journal of Antibiotics · 1989 · 100 citations · Full text

Agriculture, Biochemistry, Microbiology +10

A novel<i>β</i>‐sheet breaker, RS‐0406, reverses amyloid<i>β</i>‐induced cytotoxicity and impairment of long‐term potentiation<i>in vitro</i>

Yasuhiro Nakagami, Satoko Nishimura, Takako Murasugi et al. · British Journal of Pharmacology · 2002 · 92 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17